Associate Principal Scientist – Advanced Drug Delivery

AstraZeneca•Waltham, MA

1d•Onsite

About The Position

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life-changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being ambitious, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. About AstraZeneca in Waltham, MA: Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility supports a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most groundbreaking technology and lab spaces, all developed to encourage collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Summary of the group: Pharmaceutical Sciences is a department within AstraZeneca Biopharmaceuticals R&D with a mission to transform molecules into investigational medicines, meeting the unmet needs of future patients. Advanced Drug Delivery is a department within Pharmaceutical Sciences. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas and our mission is to transform diverse modalities into investigational medicines.

Requirements

PhD degree in Pharmaceutical Sciences, Analytical Chemistry, Material Sciences, Biomedical Engineering, Chemical Engineering or related scientific disciplines with minimum 3 years, preferably 5+ years post-graduation experience in pharmaceutical and/or biotechnology environment.
Or MS degree in Pharmaceutical Sciences, Analytical Chemistry, Material Sciences, Biomedical Engineering or related scientific disciplines with minimum 7 years, preferably 10+ years industry experience in pharmaceutical and/or biotechnology environment.
Knowledge and hands-on experience with analytical instruments for the characterization of formulation and drug products particularly in separation and chromatography (e.g., HPLC/UPLC, LC/MS, DLS, DSC, TGA, DVS, PXRD, dissolution)
Demonstrated ability in designing and optimizing formulations of poorly soluble compounds for preclinical studies including PROTACs & RIPTACs
Knowledge and hands-on experience of enabling formulation technologies including but not limited to amorphous solid dispersion, lipid-based formulation and nanoparticles
Strong analytical, problem-solving skills
Track record of scientific excellence in terms of scientific publications, patents, and/or conference presentations
Excellent oral and written communication skills
Ability to effectively lead scientific/project activities
Committed to effective methods through a structured approach and growth mindset

Nice To Haves

Willingness to acquire new skills or technologies
Work independently and collaboratively in team settings
Modeling and simulation predictions for human oral absorption of drug products
Broad knowledge and in-depth understanding of drug discovery and drug development
Understanding of principals and applications of GLS/GLP/GMP

Responsibilities

Developing analytical methods, formulations, and drug delivery systems with a focus on small molecules
Serving as a function representative and providing pharmaceutical expertise to global project teams
Planning and conducting experiments with minimum supervision
Generating, evaluating, and reporting data clearly and reliably
Providing data interpretation and making recommendations to project teams and other stakeholders.
Being actively involved with novel formulation development and innovative technology evaluation.
Working as a member of cross-functional pharmaceutical science and CMC project teams, in close collaboration with other formulators, analytical chemists, chemists and biologists at AstraZeneca
Presenting data at internal AstraZeneca meetings and occasionally at external meetings