Associate Principal Scientist, Synthetic Purification AR&D
About The Position
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to use innovative thinking, state-of-the-art facilities, and robust scientific methodology, we collaborate to discover the next medical breakthrough. As an Associate Principal Scientist in the multiscale separations team within the Separations Sciences team of Analytical Enabling Capabilities, you will work within a highly collaborative team to enable the advancement of the development pipeline. You will be primarily responsible for chromatographic isolation of pharmaceutical API and impurities from analytical scale to semi-prep scale and prep scale, covering the space of small molecules, peptides, conjugate-based modalities as well as emerging modalities in our portfolio. To accelerate the development of new medicines and vaccines, you will partner with process chemists and analytical scientists to deploy efficient and fit-for-purpose chemical isolation methods, to establish innovative purification workflows, and to deliver high purity materials. As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.
Requirements
- Expertise in analytical, semi-prep/prep scale chromatography (RPLC, NPLC, SFC), technologies, instrumentation, and workflows, with demonstrated experience in its applications in chiral, achiral isolation of challenging pharmaceutical mixtures to support a variety of pharmaceutical modalities including small molecules, peptides, antibody-drug conjugates and vaccines adjuvants etc.
- Experience in mass spectrometry and its application in MS-directed chromatographic purification.
- Working knowledge of orthogonal detection technologies, including PDA, Multi-angle light scattering, charged aerosol detection etc.
- Creative problem solving in scientific research and development, with proven track-record of translating R&D problem solving into impactful pipeline deliveries.
- Experience in mentoring peers.
- External scientific engagement that may include a combination of publications, industry white paper contributions, presentations at scientific meetings.
- Excellent scientific writing and verbal communication skills.
Nice To Haves
- Pharmaceutical GMP experience is highly preferred.
- Hands-on experience using Teledyne ISCO-MS systems
Benefits
- medical, dental, vision healthcare and other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays
- vacation, and compassionate and sick days
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
