Co-op: Platform Technologies & Innovation

Prime Medicine • Cambridge, MA

1d • $23 - $33

About The Position

Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in molecular/cell biology-related wet-lab work to join the Prime Editing Platform team. The candidate will contribute to the development of RNA innovations that advance Prime Medicine’s platform capabilities. The qualified candidate will work with a highly collaborative, fast-paced team to design, screen, optimize and validate Prime Editor mRNAs in relevant cell models to support and expand mRNA-based screening efforts. In parallel, the candidate will help drive the exploration and development of RNA modalities across the organization. The candidate will receive consistent mentorship from experienced scientists and learn a variety of different lab-based techniques and skills. Furthermore, the co-op will learn about data analysis and will have an opportunity to present his/her/their work in team meetings. In this position, the candidate will develop a deep understanding of RNA technologies and gene editing and how these efforts fit into the overall drug discovery process.

Requirements

• B.S. /M.S. candidate in in Cell & Molecular Biology, Chemical Biology, Biochemistry, or related majors.
• Firm understanding of, molecular biology, cell biology, and biochemistry. Background understanding of genome editing is a plus.
• Previous wet-lab (molecular/cell biology) experience.
• Excellent troubleshooting and communication skills.
• Interested in solving complex problems in a cross functional collaborative environment.

Nice To Haves

• Familiar with cell-based assays, mammalian cell culture and transfection, and nucleic acid biochemistry.
• Excels at some of the following lab techniques: PCR, nucleotide extraction, molecular cloning, ELISA, etc.
• Ability to use Word, Excel, PowerPoint, and GraphPad Prism for data documentation, analysis, and presentation.
• Experience with computational molecular biology tools (e.g., DNA visualization software)

Responsibilities

• Conduct mRNA production via in-vitro transcription (IVT) and purification.
• Maintain mammalian cell culture, perform cell passaging.
• Transfect mammalian cells with Prime Editing reagents to determine gene editing activity.
• Execute and develop routine cell-based assays to screen for novel mRNA constructs.
• Perform analytical procedures including ELISA, luciferase assay, qRT-PCR assay and gDNA.
• Maintain a timely and well-organized electronic lab notebook (ELN).
• Provide preliminary data analysis, interpretation, and contribute to presentations within Platform team and cross functional teams.

Benefits

• Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

What This Job Offers

• Career Level: Intern