Computational Biologist

Alta Genetics • Madison, WI

1d

About The Position

URUS is seeking a Computational Biologist to join our Innovation group as part
of the team focused on Genetic Advancement and Trait Discovery. This role is
suited for a creative and career motivated individual who brings strong
expertise across multiple disciplines of genomics, bioinformatics, and systems
biology. The successful candidate will lead the integration, analyses and
interpretation of genomic and multi-omics data to identify biological pathways,
DNA sequence motifs or genomic variation for rationale design of genetic traits
to express phenotypes that significantly improve fertility, protein quality,
health or well-being across cattle breeding systems.

Acceligen®, as part of the URUS group of brands, is the global leader for
deployment of gene-edited traits in cattle. Acceligen has more than a decade of
proven commercial expertise in trait deployment through new breeding
technologies and advanced reproductive technologies. Acceligen works within a
collaborative environment that includes URUS Digital, PEAK Genetics, Trans Ova
Genetics, Leachman Cattle CO., and VAS with a common goal to breed “Better Cows
for a Better World”. The incumbent will report to the Chief Science Officer of
Acceligen, who leads the Genetic Advancement and Trait Discovery team as part of
the Innovation group at URUS. This position will be based in Madison, WI or New
Brighton, MN.

Requirements

• Ph.D. in Computational Biology, Systems Biology, Genome Science, or a related field.
• Deep understanding of genetics, molecular biology, biochemistry, cellular functions, and organismal systems.
• Expertise in probability, statistical modeling, and algorithm design.
• Principles of programming, data structures, algorithms, high-performance computing (HPC), and database management.
• Knowledge of specific tools, databases, and analysis methods for genomic/proteomic data.
• Proficiency in languages like Python (with libraries like Pandas, NumPy, scikit-learn) and R. Experience managing bioinformatics pipelines in Unix/Linux environments.
• Strong skills in data mining, machine learning (deep learning, pattern recognition), and biostatistics. Proficient in genome-wide association studies (GWAS) and fine-mapping methods to identify causal variants and regulatory regions.
• Ability to manage, integrate, analyze, and visualize large, complex datasets (e.g., Next-Gen Sequencing data and other Omics datasets).
• Experience with mathematical modeling of biological processes and molecular dynamics.
• Excellent analytical thinking to translate biological questions into computational problems (e.g. demonstrated skill to integrate multi-omics datasets to identify target genes or regulatory motifs/mechanisms within the expressed genome that link genotype to phenotype).
• Required communication skills are fluency in English. Ability to explain complex technical findings to both technical and non-technical audiences. Includes working and communicating within interdisciplinary teams (e.g., molecular and quantitative geneticists, data scientists, and reproductive biologists). Incumbent is solely responsible for analyzing, interpreting, and reporting research data. Results, in the form of manuscripts, reports, and presentations at scientific meetings, are considered authoritative and technically accurate.
• Skill in formulating hypotheses, finding relevant data, and designing computational experiments.
• Eagerness to learn new methods and tools to tackle evolving biological challenges.
• Precision in coding, data interpretation, and validation.
• Incumbent is responsible for planning specific research approaches and designing experimental schemes to achieve research objectives.
• Contribute to long-term research planning and innovation strategies, which include active participation in team and cross-functional meetings.
• Originality and creativity are required to integrate appropriate company resources, methodologies, technologies into a cohesive set of analyses that successfully characterize genome structure and function.
• Originality and creativity are also required to integrate complex datasets from separate functional and structural genome studies into a federated database that channel subsequent studies towards elucidating how alterations in complex biological processes affect phenotypic expression.

Nice To Haves

• Knowledge and experience in working with genomic and genetic data from food animals is preferred.
• Proven experience in identifying causal variants is preferred.
• Knowledge of Snakemake, Microsoft Azure and Azure Databricks is preferred.

Responsibilities

• Deliver tools and knowledge that facilitate commercial implementation for advancing goals in the URUS breeding program.
• Analyze large biological datasets, model complex systems, and develop predictive tools.
• Translate biological questions into computational problems.
• Integrate multi-omics datasets to identify target genes or regulatory motifs/mechanisms within the expressed genome that link genotype to phenotype.
• Plan specific research approaches and designing experimental schemes to achieve research objectives.
• Contribute to long-term research planning and innovation strategies, which include active participation in team and cross-functional meetings.
• Integrate appropriate company resources, methodologies, technologies into a cohesive set of analyses that successfully characterize genome structure and function.
• Integrate complex datasets from separate functional and structural genome studies into a federated database that channel subsequent studies towards elucidating how alterations in complex biological processes affect phenotypic expression.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree