Director, DMPK

Foghorn Therapeutics•Watertown, MA

13h•$200,000 - $240,000

About The Position

This position offers an exciting opportunity to be a key part of a research and development organization that is pioneering a new class of medicines. The Director, DMPK project representative, will provide direct support to multiple project teams across the discovery and early clinical development portfolio.

Requirements

PhD or equivalent in relevant field
7+ years of experience in pharmaceutical/biotechnology setting
Strong understanding of DMPK principles and ADME/PK assays in drug development
Demonstrated expertise in human PK and dose projections
Proven track record as DMPK project representative/leader on multiple project teams
Up-to-date knowledge of regulatory guidance related to ADME/PK characterization, drug-drug interaction, and human ADME studies
Experience with IND preparation and other regulatory documents
Strong communication and collaboration skills with ability to effectively convey ADME/PK risks
Demonstrated ability to work effectively in cross-functional team environments

Nice To Haves

Experience with covalent modalities, PROTACs and parenteral delivery preferred

Responsibilities

Design and execute issue-driven ADME/PK studies to address critical discovery project needs, supporting program progression through lead optimization to early development
Analyze and interpret preclinical ADME/PK data, communicating results and recommendations to project teams effectively
Build and maintain strong collaborations with internal and external partners across chemistry, biology, pharmacology, CMC and other R&D disciplines
Partner with discovery and clinical groups to design preclinical studies that inform clinical dosing strategy
Contribute to key decisions including candidate selection, development strategy, and clinical trial design
Author and review preclinical study reports, including nonclinical toxicology, DMPK and biomarker sections of regulatory documents
Design and interpret PK/PD, efficacy and toxicology studies in collaboration with cross-functional teams
Stay current with DMPK scientific literature and emerging technologies to identify potential applications for ongoing programs
Help finalize clinical study protocols and reports with focus on DMPK aspects

Benefits

Highly competitive and inclusive medical, dental and vision coverage options
BCBS PPO and PPO HSA plans
BCBS Dental Plan
EyeMed Vision Plan
FSA and HSA for medical expenses and dependent care expenses
401(k) Program via Fidelity with the company match
Corporate Wellness Program
Unlimited Paid Time Off policy
Winter shut down
12 weeks of 100% paid parental leave for birthing/primary parent and primary guardian in case of adoption and 3 weeks of 100% paid parental leave for non-birthing/non-primary parent/guardian.
Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
Free parking, subsidized commuter passes, or a $100 monthly stipend for walking/biking to work
Company lunches on Wednesdays