Director, People and Culture Business Partner

Prime Medicine • Cambridge, MA

2d • Onsite

About The Position

Prime Medicine is seeking a Director, People and Culture Business Partner — a passionate, people-first HR professional who is as comfortable shaping culture as they are rolling up their sleeves on the operational fundamentals that keep a growing biotech humming. Reporting to the VP, Senior People and Culture Business Partner, you'll be a trusted partner to Prime's management and employees alike - someone who connects deeply with the business, champions our culture, and helps ensure our people strategy keeps pace with our science. At Prime, People & Culture is a strategic driver of our mission. This role is for someone who works hard, has fun, and genuinely believes that great organizations are built one person, one team, and one conversation at a time.

Requirements

• An advanced degree in Human Resources, Business, Life Sciences, or a related field.
• 10–12+ years of progressive HR experience, with significant HRBP experience supporting managers and employees.
• Deep experience in biotechnology, pharmaceuticals, or life sciences — you understand the cadence, culture, and complexity of science-driven organizations.
• A startup mentality with an operator's mindset: you know when to build from scratch, when to borrow a best practice, and when to just get it done.
• Demonstrated success juggling multiple priorities in a fast-moving environment without losing sight of the details or the people.
• Strong business acumen and executive presence — you influence at all levels, and people trust your judgment.
• A high tolerance for ambiguity, a bias toward action, and a track record of driving measurable outcomes.
• You work hard, have fun, and make the team around you better.

Responsibilities

• Be a Culture Champion Show up as the heart of our employee experience — approachable, credible, and genuinely invested in the people you work with.
• Partner with managers and employees to reinforce and evolve Prime's culture and values as the company grows.
• Support employee engagement initiatives and translate listening efforts (surveys, conversations, data) into meaningful action.
• Help to continue to make Prime the kind of place where brilliant people do their best, most fulfilling work.
• Drive Talent Strategy Identify development opportunities that deepen our talent bench and build organizational capability for the long term.
• Support creative career pathing efforts and employee development programs that reflect Prime's startup spirit and scientific ambition.
• Serve as a true Talent Ambassador — someone employees, management, external vendors and candidates are excited to engage with.
• Partner Strategically with the Business Partner closely with management to drive organizational effectiveness, workforce planning, and thoughtful change management.
• Translate Prime's evolving business priorities and values into people strategies that create real impact.
• Lead organizational design efforts and guide teams through change with clarity and care.
• Provide counsel that's both candid and compassionate on employee relations and management challenges.
• Execute with Excellence Ensure flawless execution of core HR cycles: administration, compensation planning, promotions, talent mobility, headcount planning, recruitment, and workforce planning.
• Partner with Total Rewards to navigate compensation cycles effectively and equitably.
• Contribute to policy development and evolving compliance needs as Prime scales — with a pragmatic, startup-savvy lens.

Benefits

• Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: No Education Listed
• Number of Employees: 101-250 employees