Director, Safety Science
About The Position
The Clinical Development team is seeking a Safety Science Director to lead safety science and pharmacovigilance (PV) at Maze. In this highly visible leadership role, you will set the safety strategy across our clinical programs, spanning both common and rare diseases in nephrology and cardiometabolic indications. You will have end-to-end responsibility for safety surveillance, adverse event reporting, risk management, and PV governance, while partnering closely with Clinical Development, Regulatory, Biostatistics, and Clinical Operations. As Maze advances programs from early to late-stage development, you will play a critical role in shaping safety strategy, influencing decision-making, and ensuring patient safety remains central to our work. This position reports to the Head of Clinical Development.
Requirements
- Advanced degree in health sciences (MD/DO, PharmD, PhD) with 4+ years of experience in pharmacovigilance and drug safety.
- Deep knowledge of global pharmacovigilance regulations and safety requirements.
- Experience with medical review of individual case reports, signal detection, trend analysis, and risk mitigation plans
- Proven experience preparing and reviewing safety reports and responding to regulatory inquiries
- Demonstrated ability to manage and influence external CROs and vendor partners
- A positive, adaptable, and collaborative leadership style with high ethical standards
- Ability to travel domestically up to 10-15% for internal and external meetings
Nice To Haves
- Experience in late-stage clinical development is preferred.
Responsibilities
- Lead safety surveillance and signal identification activities, proactively identifying risks and developing mitigation strategies
- Provide strategic and operational oversight for case processing, adverse event reporting, and regulatory compliance
- Oversee the preparation, review, and submission of aggregate safety reports and safety sections of clinical and regulatory documents
- Author and maintain safety-related content for clinical protocols, IBs, CSRs, and regulatory submissions
- Lead the Safety Management team, fostering a culture of accountability, development, and scientific rigor
- Partner cross-functionally to develop and execute Safety Management plans aligned with program and corporate objectives
- Serve as key safety representative in internal governance forums and external discussions with KOLs, advisors, and health authorities.
- Provide oversight and strategic direction for outsourced pharmacovigilance activities, including CROs, consultants, and vendors
- Anticipate operational or compliance risks and proactively remove barriers to program and organizational success
Benefits
- Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Director
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
