Executive Director, Global Medical Lead (LC-FAOD, MPS VII and MPS IIIA)

Ultragenyx Pharmaceutical

5d•Remote

About The Position

Ultragenyx is seeking an experienced physician leader to serve as Executive Director, Global Medical Affairs & Strategy, providing strategic medical leadership across key rare disease programs, including LC‑FAOD, MPS VII, and MPS IIIA. In this role, you will guide global medical strategy for both approved therapies (Dojolvi and Mepsevii) and an investigational AAV gene therapy for MPS IIIA. You will shape and drive integrated evidence generation, scientific communications, external engagement, global launch preparation, and lifecycle strategy across a diverse and evolving portfolio. Reporting to the VP, Global & US Medical Affairs and Strategy, the Executive Director will operate as a trusted scientific and strategic leader—collaborating cross‑functionally, influencing decisively, and navigating the complexities of metabolic and neurodegenerative genetic diseases. This is a high‑impact, career‑defining opportunity for a medical affairs leader passionate about advancing the future of rare disease medicine.

Requirements

Medical Doctor (MD) required. MD, PhD strongly preferred. 7+ years of combined industry and academic experience preferred. Board Certification or equivalent in Clinical/Biochemical Genetics or Neurology preferred
Proven expertise in the management of patients with inherited metabolic and/or neurodegenerative rare diseases
Recognized scientific authority with the ability to engage in advanced scientific and clinical discussions with both internal and external experts
Proven leadership skills including a passion for collaboration and understanding all stakeholder perspectives to drive alignment and decision-making
High aptitude for attention to detail, commitment to high-quality work, and a sense of passion and urgency to achieve goals and improve the lives of patients
Proven ability to take initiative and drive successful execution of complex projects
Highly analytical and strategic thinker with the ability to identify interdependencies, consider medical implications, and understand the broader goals of a program and the organization
Excellent communication skills, with the ability to effectively articulate scientific and strategic concepts in both written documents and verbal presentations
Demonstrated success leading cross functional or multidisciplinary teams, ideally in both academia and biotech
Willingness and ability to travel up to 15%, including domestic and international engagements

Responsibilities

Serve as Global Medical Lead for LC-FAOD (Dojolvi) and the MPS programs, including MPS VII (Mepsevii) and MPS IIIA (UX111)
Lead the Global Medical Sub Teams (GMSTs), setting the strategy for the programs, ensuring cross regional alignment, and driving timely execution of annual medical plan
Guide and oversee prelaunch planning, launch execution, and postlaunch optimization across the globe
Serve as the strategic medical leader on the Program Core Team and related sub-teams, shaping development, commercialization, and lifecycle strategies. Work decisively to overcome challenges and drive program priorities forward
Own, develop, and update the Integrated Evidence Generation Plans (IEPs) for all assigned programs ensuring cross functional alignment to address global/regional evidence gaps
Oversee global Real World Evidence initiatives, including ISTs and collaborative research that inform clinical decision making and regulatory objectives.
Accountable as the medical affairs lead for Disease Monitoring Programs for LC-FAOD and MPSs, providing strategic medical leadership on all aspects of the study and accountable for leading data generation and publication activities aligned to the IEP
Lead advisory boards, steering committees, and investigator meetings to gather key insights that inform program strategy and activities
Provide deep disease area and product expertise, ensuring accurate and consistent communication of clinical and scientific data
Direct global publication strategy and congress planning activities, ensuring timely, high-impact dissemination of data and other education initiatives
Lead training and provide strategic guidance and tools to regional medical affairs teams to ensure launch readiness and consistent scientific exchange
Build and maintain relationships with global KOLs, academic centers of excellence, scientific societies and advocacy groups to inform strategy and amplify scientific reach
Monitor competitors and landscape changes, translating insights into strategic actions.