Executive Medical Director & Head of Global Real-World Evidence, Clinical Epidemiology

Sarepta Therapeutics • Cambridge, MA

1d • Hybrid

About The Position

The Executive Medical Director, Head of Global Real-World Evidence & Clinical Epidemiology is a senior physician-scientist leader responsible for shaping and executing an integrated real world evidence strategy across Sarepta’s portfolio. This role ensures that medical insight, epidemiologic understanding, and real-world evidence are aligned to inform clinical development, regulatory strategy, safety evaluation, payer value demonstration, and lifecycle management. Serving as a core leader within cross-functional governance, the role bridges Development, Medical Affairs, Safety, Regulatory, and Customer teams to generate credible, stakeholder-relevant real-world evidence that strengthens differentiation, reimbursement readiness, and patient impact.

Requirements

• MD required; additional graduate training in epidemiology, public health, health economics, or related field strongly preferred
• ~15+ years of biopharmaceutical experience with Medical Affairs, HEOR, RWE, epidemiology, or related fields
• Demonstrated leadership of global real world evidence generation programs across development and post-launch stages
• Experience engaging regulators, HTA bodies, payers, and academic collaborators
• Strong publication and scientific leadership track record
• Candidates must be authorized to work in the U.S.

Nice To Haves

• Deep expertise in rare and specialty disease a plus
• Advanced methodological expertise in RWE and causal inference
• Experience integrating AI/data science approaches into evidence generation and digital measurement strategies
• Proven success building multidisciplinary evidence generation organizations

Responsibilities

• Medical & Integrated Real World Evidence Strategy
• Provide leadership for global real world evidence generation strategies spanning early development through post-launch lifecycle stages
• Ensure clinical relevance is embedded across RWE and epidemiology programs
• Partner with Clinical Development for natural history insights, and real-world evidence with unmet medical need and differentiation strategy
• Translate disease understanding and treatment impact into coherent medical narratives supporting regulatory, payer, and scientific engagement
• Real-World Evidence Strategy & Execution
• Establish and lead enterprise RWE strategy supporting effectiveness, safety, utilization, adherence, and economic outcomes
• Oversee RWE studies leveraging claims, EHRs, post hoc analysis and other RWD
• Advance innovative methodologies including causal inference, target trial emulation, hybrid trial designs, and digital biomarkers
• Implement governance frameworks ensuring scientific rigor, transparency, and regulatory credibility of RWE programs and studies
• Actively develop publication and other communication plans for new RW evidence
• Clinical Epidemiology & Disease Understanding
• Lead clinical epidemiology strategy supporting development, safety, and value decision-making
• Oversee incidence, prevalence, morbidity, mortality, and real world burden-of-illness analyses, particularly in rare disease populations
• Direct natural history studies, systematic literature reviews, and predictive disease modeling
• Provide epidemiologic expertise for pharmacovigilance, safety assessments, and regulatory documentation
• Scientific Leadership & External Engagement
• Serve as a recognized RWE thought leader internally and externally
• Build strategic collaborations with academia, data partners, and patient groups
• Lead publication strategy advancing disease understanding, methodological innovation, and treatment value as it relates to RWE and clinical epidemiology
• Represent the organization in advisory boards, regulatory interactions, and scientific forums as required
• Cross-Functional & Organizational Leadership
• Serve as a core member of global program teams and governance bodies shaping development and commercialization strategy
• Provide oversight of research budgets, vendors, and evidence governance processes
• Lead initiatives that strengthen integration of medical insight and evidence generation across the organization

Benefits

• We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
• Physical and Emotional Wellness
• Financial Wellness
• Support for Caregivers
• Sarepta Therapeutics offers a competitive compensation and benefit package.

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Education Level: Ph.D. or professional degree