In Vivo Principal Scientist, Immunology

Synolo Therapeutics • Cambridge, MA

19h

About The Position

Synolo Therapeutics, an early-stage biotechnology company launched by RA Ventures, is pioneering the development of precision-targeted immunotherapies for cancer. Powered by computational protein design and proprietary technologies that yield biological data sets at unprecedented scale and resolution, we are building a pipeline of first-in-class multi-specific biologics with novel functionalities. Synolo was founded by pioneers in the field of protein design and engineering, synthetic biology, DNA sequencing, immunology, and biologics drug discovery and development.

RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. TechAtlas' analyses are captured in a unique collection of competitive landscapes, or ‘maps’, that identify competitive therapeutics, diagnostics, research tools, and/or technological capabilities in a given area.

Synolo Therapeutics is seeking a highly strategic and hands-on Principal Scientist, In Vivo Immunology to lead the design and execution of in vivo pharmacology strategies across our multispecific biologics pipeline.

This individual will serve as the in vivo immunology subject matter expert, responsible for architecting disease models, defining study endpoints, driving translational hypotheses, and ensuring rigorous, data-driven decision-making across programs. As a key scientific leader, you will work closely with internal stakeholders and external partners to advance molecules from discovery through preclinical development.

This is a high-impact role for a scientist who thrives in a fast-paced startup environment and is motivated by building scientific capabilities that directly shape pipeline strategy.

Requirements

• Demonstrated expertise in immunology and in vivo pharmacology, particularly in the evaluation of biologics.
• Demonstrated experience designing and executing complex in vivo mouse models to interrogate immune function and therapeutic activity.
• Strong understanding of biologic modalities, including antibodies and multispecific constructs.
• Experience integrating PK analysis (e.g., WinNonlin) and bioanalytical assays into pharmacology studies.
• Deep hands-on experience in immune profiling techniques, including multi-parameter flow cytometry (FACS), immunohistochemistry (IHC), ELISA, and MSD.
• Proven ability to independently drive scientific strategy while collaborating effectively in cross-functional teams.
• Analytical and detail-oriented, with the ability to manage multiple priorities in a fast-paced environment.
• Excellent written and verbal communication skills, with the ability to clearly articulate complex scientific concepts.
• PhD, MS, or BS in Immuno-Oncology, Immunology, Cell Biology, or a related field. A minimum of 5 years of relevant industry experience is required for PhD candidates, 10 years for MS candidates, and 15 years for BS candidates.

Nice To Haves

• Experience advancing biologic therapeutics from discovery through IND-enabling studies, including development of translational strategies that connect in vivo findings to clinical hypotheses.
• Prior experience building or scaling in vivo pharmacology capabilities within a growing biotech environment, influencing program direction and cross-functional decision-making.

Responsibilities

• Lead in vivo pharmacology strategy across one or more discovery-stage programs, shaping experimental direction and program-level decisions.
• Design and refine disease-relevant murine models (e.g., syngeneic, humanized, immune-competent) to evaluate multispecific biologics.
• Design studies, define endpoints, and establish biomarker strategies to interrogate mechanism of action and therapeutic differentiation.
• Oversee and critically evaluate outsourced in vivo studies conducted at CROs, ensuring scientific rigor and data integrity.
• Lead hands-on in vivo and ex vivo experimentation, including dosing (IV, IP, SC), tumor inoculation, tissue collection, and immune profiling (flow cytometry, ELISA, MSD).
• Integrate and interpret complex in vivo and PK/PD datasets, translating findings into actionable recommendations for cross-functional teams and leadership.
• Establish best practices for experimental design, documentation, and data quality, maintaining high standards within the immunology function.
• Mentor and provide scientific guidance to junior team members.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree