Postdoctoral Scholar Malaria Immunology

University of South Florida • Tampa, FL

1d

About The Position

The Sather Laboratory at the University of South Florida (USF) is seeking a
highly motivated Postdoctoral Scholar to lead research focused on defining the
features and characteristics of potent naturally acquired protective immunity.
Rather than focusing on traditional immunization strategies, this role utilizes
natural prototypes—human monoclonal antibodies (mAbs) developed during natural
infection—to guide next-generation vaccine development. These naturally acquired
antibodies provide a blueprint for how the immune system recognizes antigens in
their most native-like format and are invaluable tools for structure-guided
antigen design.

The selected fellow will interrogate naturally acquired immunity from human
subjects with defined infection histories to identify and characterize
protective antibody prototypes. This work involves a reverse vaccinology
approach: mining human B cell sequences to define the structural interactions
most critical for protection and using those insights to iteratively improve and
stabilize candidate antigens for optimal recognition by human antibody
repertoires. The researcher will create a comprehensive antigenic map to drive
the production of highly optimized, next-generation immunogens.

Responsibilities

• Interrogate naturally acquired immunity from human subjects with defined infection histories to identify and characterize protective antibody prototypes.
• Mine human B cell sequences to define the structural interactions most critical for protection.
• Iteratively improve and stabilize candidate antigens for optimal recognition by human antibody repertoires.
• Create a comprehensive antigenic map to drive the production of highly optimized, next-generation immunogens.

Benefits

• medical, dental and life insurance plans
• retirement plan options
• employee and dependent tuition programs
• generous leave
• hundreds of employee perks and discounts

What This Job Offers

• Job Type: Full-time
• Education Level: No Education Listed
• Number of Employees: 5,001-10,000 employees