Postdoctoral Scholar TBV Vaccine Discovery
About The Position
The Sather Laboratory at the University of South Florida (USF) is seeking a highly motivated Postdoctoral Scholar to join an NIH-funded multi-disciplinary research team focused on discovering and developing novel malaria transmission-blocking vaccine (TBV) candidates. This project utilizes a reverse vaccinology approach—combining proteomics, bioinformatics, and immunology—to identify surface-exposed proteins on early mosquito-stage Plasmodium falciparum parasites. Working in close partnership with experts in proteomics, the selected fellow will be responsible for translating high-priority protein leads into viable vaccine immunogens. The researcher will lead the development of novel vaccine candidates, overseeing the entire pipeline from in silico protein design to functional evaluation. This includes the recombinant expression and purification of difficult-to-produce Plasmodium proteins, conducting mouse immunization campaigns, and isolating monoclonal antibodies (mAbs) to characterize protective epitopes. The fellow will apply advanced protein biochemistry and biophysical techniques to validate the stability and antigenicity of these new targets.
Responsibilities
- Lead the development of novel vaccine candidates
- Oversee the entire pipeline from in silico protein design to functional evaluation
- Recombinant expression and purification of difficult-to-produce Plasmodium proteins
- Conduct mouse immunization campaigns
- Isolate monoclonal antibodies (mAbs) to characterize protective epitopes
- Apply advanced protein biochemistry and biophysical techniques to validate the stability and antigenicity of new targets
Benefits
- first-class benefits package includes medical, dental and life insurance plans, retirement plan options, employee and dependent tuition programs, generous leave, and hundreds of employee perks and discounts
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What This Job Offers
Career Level
Entry Level
Education Level
No Education Listed
Number of Employees
5,001-10,000 employees
