Principal Scientist, Antibody-Drug Conjugate Chemistry

About the position

As a member of the biotherapeutics group, the incumbent will play a key role in supporting the group's discovery and preclinical development efforts by utilizing skills and experience in chemical synthesis and purification/characterization. The incumbent will be responsible as a vital role in this mission through discovering and advancing novel ADC linker/payload technologies for targeted cancer therapies. The ideal candidate will have excellent skills and hands-on experience in conducting multi-step syntheses for novel ADC payloads, drug linkers, and key intermediates, possessing high motivation to perform bioconjugation. Experience in bioconjugation and/or bioconjugate analyses such as HPLC or Q-TOF MS is a plus.

Responsibilities

• Design, synthesis, purification, and characterization of small molecule lead compounds
• Troubleshoot and optimize multi-step synthetic routes
• Provide ADC expertise in state-of-the-art ADC technologies including linkers, payloads and bring novel ideas to POC
• Interact and collaborate with internal departments and external colleagues to discuss and resolve project needs and issues in research and early development of ADCs
• Provide support in evaluation of ADC research platforms and preclinical licensing candidates as needed
• Provide critical scientific/technical data analysis, interpretation of experiments and report writing
• Effectively communicate scientific concepts, study findings and interpretations to multi-disciplinary teams
• Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement
• Work externally facing with development partners to implement joint research projects, including presentation of findings and experimental data at scientific meetings
• Follow company intellectual property and compliance policies and practices
• Comply with company health and safety policies and general laboratory practices

Requirements

• Bachelor's degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of eleven years of experience in the biotechnology/pharmaceutical industry
• Master's degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of nine years of experience in the biotechnology/pharmaceutical industry
• PhD degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of five years of experience in the biotechnology/pharmaceutical industry
• Hands on laboratory experience in medicinal discovery including critical reagent generation, identification and optimization of small molecule, payloads, and drug-linkers
• Hands on laboratory experience in small molecule characterization
• Seeking experience in bioconjugation
• Experience in a variety of analytical instruments and technologies including HPLC, LC/MS, NMR to enable structural determination and purity assessment
• Analyze and accurately record data using Electronic Laboratory Notebooks
• Experience writing summaries, reports, presenting scientific data/results to internal and external collaborators

Nice-to-haves

• Familiarity with general components of bioconjugation and ADC

Benefits

• 401k plan with generous company contributions
• Group medical, dental and vision coverage
• Life and disability insurance
• Flexible spending accounts
• Discretionary annual bonus program
• Sales-based incentive plan for field sales staff
• Opportunity to purchase company stock
• Long-term incentives
• 15 accrued vacation days in the first year
• 17 paid holidays including a company-wide winter shutdown in December
• Up to 10 sick days throughout the calendar year