Principal Scientist, Applied and Translational Omics
About The Position
You will lead applied and translational omics analyses that turn complex biological data into clear decisions. You will work with experimental scientists, data engineers, and clinical teams to design analyses and integrate multi-omic and clinical data. We value clear communication, practical problem solving, curiosity, and collaboration. This role offers visible impact, career growth, and aligns with our mission of uniting science, technology and talent to get ahead of disease together. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: - Design and run reproducible analyses of genomic, transcriptomic, proteomic and other omics datasets. - Integrate multi-omic and clinical data to prioritize targets, nominate biomarkers, and define patient subgroups. - Build, validate and productionize analysis pipelines and tools that support cross-functional teams. - Communicate results clearly and make practical recommendations to project teams and decision-makers. - Collaborate with laboratory and clinical colleagues to design analyses that guide experiments and studies. - Ensure data quality, metadata standards, documentation and reproducible research practices.
Requirements
- Advanced degree (Master’s with relevant experience or PhD preferred) in computational biology, bioinformatics, genetics, biostatistics, or related field.
- Programming experience in R and/or Python for data analysis and scripting.
- Experience processing and analyzing large omics datasets, including quality control and normalization.
- Experience with common genomics file formats and tools (for example VCF, BAM/FASTQ, single-cell data structures).
- Experience reproducible analyses and use of version control (for example Git).
Nice To Haves
- Clear communication skills and experience working in multidisciplinary teams.
- Experience integrating omics with clinical or real-world data for translational analyses.
- Familiarity with cloud or distributed compute environments (BigQuery, Spark, Nextflow, Docker).
- Knowledge of statistical genetics, genome-wide association studies and post-GWAS methods.
- Experience with single-cell, spatial omics, or proteomics analysis workflows.
- Experience productionising pipelines or contributing to shared analysis platforms.
- Evidence of influencing research through publications or major project contributions.
Responsibilities
- Lead hands-on analysis of large, diverse omics datasets, including bulk and single-cell data.
- Apply statistical methods, machine learning, and causal inference to answer translational questions.
- Develop scripts, workflows, and software artifacts that follow reproducible research and FAIR principles.
- Troubleshoot data issues, perform rigorous quality control and document analysis steps.
- Mentor junior scientists and contribute to a collaborative and respectful team culture.
- Monitor new methods and tools and evaluate them for adoption in projects.
Benefits
- Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
- Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
