Principal Scientist, Global Proteomics

Johnson & Johnson•Cambridge, MA

1d•Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine We are searching for the best talent for a Principal Scientist, Global Proteomics to be located in Cambridge, MA. Purpose: Do you want to use your hard‑earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high‑scale proteomic analysis ! Be part of a motivated team deploying innovative mass spectrometry technologies to tackle challenges in end‑to‑end drug discovery and development across a leading multiomics organization. We work shoulder‑to‑shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients! In this role, you will lead global target deconvolution proteomics efforts at scale. You’ll build robust, automated workflows and partner with experts across the organization to translate clear, reproducible data into meaningful insights that propel programs forward.

Requirements

A Doctorate degree in Analytical Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Pharmacology or a related field is required.
6+ years of hands‑on proteomics mass spectrometry experience, including 3+ years in a drug discovery setting (pharma, biotech, or equivalent applied environment) is required.
Demonstrated leadership in unbiased, probe‑free target deconvolution (e.g., CETSA/TPP, LIP‑MS, SPROX, PISA, limited‑proteolysis/structural proteomics), from study design through interpretation is required.
Proven track record industrializing methods: automation‑supported sample prep, robust QC, SOPs, and multi-operator reproducibility is required.
Strong communication and cross‑functional collaboration skills; effective planning and the ability to run several projects in a fast‑paced environment is required.
Technical toolkit – Experience with at least one tool from each area is required: LC‑MS & LC systems: Thermo Orbitrap Exploris/Eclipse/Fusion Lumos/Astral; Bruker timsTOF; Vanquish Neo, Evosep One, Dionex UltiMate.
Automation Platforms: Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, Dynamic Devices Lynx.
Data analysis (label‑free included): Proteome Discoverer, MaxQuant, DIA‑NN, Spectronaut, Skyline.

Nice To Haves

Experience scaling platform‑level methods and implementing automation‑ready protocols is preferred.
Expertise in PTM‑focused proteomics and/or exposure to single-cell or spatial proteomics workflows is preferred.
Record of scientific innovation (publications, patents) and external visibility (e.g., ASMS, HUPO) is preferred.
Familiarity with fit‑for‑purpose quality systems, LIMS, and FAIR data principles is preferred.

Responsibilities

Translating scientific goals into high‑throughput, automation‑ready proteomics workflows with QC and fit‑for‑purpose SOPs that enable consistency across studies and operators.
Serving as the proteomics point of contact for assigned programs; aligning on study strategy, timelines, and readouts; communicating results clearly to biology, chemistry, biologics, safety, DMPK, and clinical translation partners.
Partnering with bioinformatics and IT to ensure FAIR data practices, robust QC pipelines, and timely, decision‑ready analyses; harmonizing effort with multi‑omics colleagues for coordinated readouts.
Mentoring and uplifting teammates—sharing mass‑spec standard processes, reviewing methods and data, and contributing to a culture of scientific excellence, safety, and continuous improvement.

Benefits

Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year.
Bonuses are awarded at the Company’s discretion on an individual basis.
Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
Caregiver Leave – 10 days
Volunteer Leave – 4 days
Military Spouse Time-Off – 80 hours