Principal Scientist - Translational Muscle Biology

UCB • Cambridge, MA

10h • Hybrid

About The Position

We are seeking an exceptional Principal Scientist to join UCB's US Neuromuscular group based in Cambridge, MA and contribute to translational biology drug discovery efforts with an emphasis on muscle biology. The candidate will be responsible for leading projects, exploring new biology, designing, characterizing and deploying in vitro or in vivo models and other cellular/biochemical assays to be utilized in early drug discovery for multiple therapeutic programs and target discovery efforts. Collaborate in a matrixed team of scientists responsible for identification and knowledge building across pathobiological pathways and patient populations including those in neuromuscular disease related to nucleotide repeat expansions, genetic mutations, muscle atrophy, mitochondrial/ lysosomal dysfunction or inflammation.

Requirements

• PhD with 12+ years or MS Degree with 18+ years in drug discovery, biology, cellular biology, bioengineering or related field.
• Deep knowledge in muscle biology, and translational assays
• Strong assay development and drug discovery knowledge
• Strong track record of publishing in high-impact journals and presenting at scientific conferences
• Deep experience with mammalian cell culture, molecular and biochemical assays
• Strong attention to detail, and enthusiasm for learning
• Proven ability to lead projects, supervise and mentor scientists is a plus

Nice To Haves

• Knowledge in mitochondrial biology is a plus

Responsibilities

• Team leadership : Supervise and mentor junior scientists, fostering a collaborative and innovative research environment.
• Project management : Oversee multiple projects, ensuring timely delivery of milestones and effective resource allocation.
• Innovation : Identify and implement new technologies and methodologies to advance muscle cell biology and translational research.
• Model Development : Design, characterize and validate primary cell or stem cell/3D models for therapeutic programs.
• Assay Execution : Conduct cell-based functional assays to characterize therapeutic hits or validate new targets that could require gene editing.
• Muscle biology : Perform in vivo and in vitro assays to enhance understanding of neuromuscular disease biology.
• Team Collaboration : Collaborate with cross-functional teams to integrate translational biology insights into therapeutic programs or new target proposals.
• Data Management : Document, analyze, and present data to internal teams.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree