The mission of the Allen Institute is to understand the principles that govern life, and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through the integration of experiments, modeling, and theory. The Allen Institute for Brain Science is at a pivotal moment in the evolution of the Brain Knowledge Platform (BKP) that supports our mission to accelerate neuroscience discovery. With contributions from a growing number of organizations, BKP has become a foundational system for structuring, integrating, and leveraging vast, diverse brain datasets. We are seeking a Principal Software Engineer to lead the next phase of BKPs technical development. This individual will play a critical role in architecting a scalable, AI-enabled platform that supports multimodal data, powers scientific tools, and integrates state-of-the-art AI models. This is a unique opportunity to apply cutting-edge software, data, and AI engineering in a mission-driven environment helping to unlock the brains complexity and catalyze new therapies and insights for human health. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.