Research Lab Manager, Infectious Disease, Dr. Pritha Sen Lab

Mass General Brigham•Boston, MA

5d•$38 - $62•Onsite

About The Position

The Sen Laboratory located in the Longwood Medical Area at Brigham and Women’s Hospital (BWH) is looking for a Research Laboratory Manager who has experience and/or expertise in performing single-cell and nuclei RNA sequencing wet bench/experimental protocols in per diem role, to support several ongoing projects in the lab. Our research lab focuses on translational human immunology studies of viral immunity and immunopathogenesis in the immunocompromised host. Knowledge gained from these studies will help to guide the design of more effective eradication strategies and treatments against various infectious pathogens.

Requirements

The applicant must have a minimum of 3 years of experience in an academic and/or laboratory research setting AND have at least 1 year of experience in executing emulsion-based single-cell/nuclei library generation and next-generation sequencing workflows and be highly organized, meticulous, and rigorous in the implementation of wet bench experimental protocols.
The applicant will work independently but be trained in best practices and supervised closely by the Principal Investigator; perform duties in accordance with established hospital policies and procedures, and conduct a variety of experiments with established methodologies; participate in the design and modification of research protocols; and contribute to figure generation and methods and results writing for abstracts, research reports, and manuscripts.
The applicant will coordinate lab activities as it relates to these specific experiments, assist in general lab management issues, and undertake quality assurance programs.
A minimum 1-year commitment is required.
Bachelor's Degree Related Field of Study required.
Experience in an academic or laboratory research setting 3-5 years required
Minimum 1 year of experience performing single-cell/nuclei library generation and next-generation sequencing workflows
Ability to make independent decisions.
Aptitude for technical problem solving.
Ability to effectively supervise others.
Excellent Organizational skills.
Must possess strong budget and management skills.
Excellent judgement and ability to interpret information.
Interest in and comfort with working with human clinical specimens
Sound degree of computer literacy with basic programs (i.e. Microsoft Word, Excel, Powerpoint) with willingness to learn Adobe Illustrator, reference managers (i.e. Zotero)
Ability to record and analyze data using basic statistics
Ability to perform a variety of routine tests and prioritize work
Outstanding interpersonal and communication skills
Ability to demonstrate highest levels of professionalism

Nice To Haves

Specialized training in genomics and or immunology would be considered favorably.

Responsibilities

Supervises and/or implements the wet-bench single-cell and sequencing operations of the lab, under the supervision of the Principal Investigator
Oversees supply inventory as it relates to high-dimensional immunophenotyping and sequencing performed in the lab, under supervision of the Principal Investigator.
Processing of clinical human blood (i.e. Ficoll for PBMC, centrifugation for plasma and serum isolation) and tissues specimens (i.e. hot and cold digestion and mechanical separation of human tissue biopsies) for single-cell and sequencing workflows from patients with bacterial, viral, and fungal infections under supervision of Principal Investigator.
Participates in the design and modification of single-cell, sequencing, and immunophenotyping research protocols.
Participates in the maintenance of specialized equipment used for single-cell, sequencing, and immunophenotyping experimental workflows.
Develops research methodologies within parameters of experimental protocols and research objectives.
With appropriate support, willing to performs data analysis using advanced statistical techniques.
Contribute to writing sections of research reports and manuscripts.
Responsible for the oversight and coordination of all lab activities, including quality assurance.
Responsible for the oversight and coordination of all scheduling of all procedures.
Responsible for troubleshooting problems and instructing others in highly specialized techniques.
If entry-level's research staff is present, responsible for supervising staff in the lab.
In collaboration with Principal Investigator, participates in budget and grant development and preparation.
Records data, summarizes, and analyzes results using basic statistics.
Prepares laboratory reagents, chemicals, instruments, and equipment.
Maintains supplies inventory in accordance with departmental procedures.
Attends lab meetings and discusses progress of work regularly with supervisor.
All other duties as assigned.