Research Scientist I

CommonSpirit Health•Phoenix, AZ

About The Position

The Ivy Brain Tumor Center at Barrow Neurological Institute is a non-conventional non-profit program offering state-of-the-art clinical trials for patients with the most aggressive form of brain cancer. It is home to the largest collection of Phase 0 trials for brain tumors in the world. Our multidisciplinary team of brain tumor specialists and scientists are accelerating drug discovery and precision medicine in neuro-oncology to identify the most promising first-in-class therapies for brain tumor patients. To facilitate the development of brain targeting therapeutics via neuro-pharmacokinetic characterization of various molecules through preclinical and clinical studies.

Requirements

MD or Ph.D. upon hire Required
Doctor Of Medicine MD or Ph.D in Epidemiology upon hire and Five (5) years or equivalent of research-related experience and data analysis following the Ph.D. or M.D. degree
Experience with a statistical package (R or Stata) preferred
Specialized c omputer analysis program experience p referred

Nice To Haves

Postdoctoral training (5+ years) in bioanalysis pharmacology medicinal or pharmaceutical chemistry areas.
Proven record of UHPLC or LC-MS/MS-based assay development and validation in compliance with CAP/CLIA regulations and/or FDA guidelines.
Experience in pharmacokinetic study design execution data analyses and interpretation.
Experience in biomedical research (cellular techniques and preclinical efficacy studies).
Experience with maintenance and troubleshooting of LC and MS systems.
Excellent organizational and analytical skills.
Ability to work independently and cohesively as part of a team.
Recommendation letters

Responsibilities

Development validation and implementation of analytical methods for various drugs drug candidates metabolites and biomarkers employing UHPLC and LC-MS/MS techniques.
Planning and conducting preclinical pharmacokinetic studies including drug formulations administration through various routes tissue perfusion harvesting and analysis.
Performing biochemical and physicochemical characterization of various molecules.
Performing pharmacokinetic data analyses and interpretation.
Oversight and implementation of multiple research projects.
Facilitates research activities in partnership with laboratory PI leveraging scientific experience.
Manuscript preparation and publishing.
Development of research projects assistance with grant proposals and applications.
Supervision and training of laboratory personnel including post-doctoral fellows PhD and undergrad students.
Preparation and delivery of research presentations at local meetings national and international conferences.
General operation maintenance and troubleshooting of lab equipment including UHPLC and LC-MS/MS.
Preparation and maintenance of required laboratory safety documentation and adherence to the guidelines and regulations in compliance with CAP/CLIA regulations and FDA guidelines.