Research Scientist II/Sr, Analytical Purification

Iambic Therapeutics, Inc • San Diego, CA

5d

About The Position

We are seeking a highly skilled and motivated Analytical/Bioanalytical Scientist with a strong focus on chromatography-based purification to join our drug discovery team. The successful candidate will play a key role in supporting high throughput purification and assay workflow to enable weekly design-make-test-analysis workflow supporting in house AI based drug discovery engine. The ideal candidate will have extensive experience in chromatographic purification, particularly SFC and/or LC purification of small molecules, along with proven skills in instrument troubleshooting, workflow optimization, and a working understanding of ADME/DMPK assay design and execution.

Requirements

• Advanced degree (M.S. with or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or related field; or equivalent industry experience
• Minimum of Ph.D and 2 years of experience OR M.S with 6 years of experience
• Extensive hands-on experience in chromatography-based purification, with deep expertise in SFC and/or LC purification of small molecules
• Strong experience operating, maintaining, and troubleshooting LC, LC/MS, and SFC systems (Shimadzu, Agilent, Sciex, preferred)
• Proven ability to diagnose and resolve common instrument and workflow issues
• Familiarity with informatics tools such as Virscidian, Pipeline Pilot, KNIME, or equivalent for purification data management
• Solid understanding of the drug discovery process from lead identification through candidate optimization
• Excellent organizational, communication, and documentation skills.
• Ability to work both independently and collaboratively in a dynamic, cross-functional research environment

Nice To Haves

• Experience developing and supporting ADME/DMPK and physicochemical assays is a strong plus

Responsibilities

• Serve as the expert for chromatography-based purification, with deep experience in SFC and LC-based purification of small molecules in a drug discovery environment.
• Develop, implement, and optimize purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration
• Design and maintain automated purification workflows to increase throughput, reproducibility, and sample quality
• Collaborate with medicinal chemistry, purification, and DMPK teams to deliver high-quality purified compounds to support lead optimization and screening.
• Provide hands-on support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments, to minimize downtime and ensure consistent lab operations.
• Partner with vendors and automation providers for service, upgrades, installations, and workflow integration
• Potential support ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as needed
• Document purification workflows, maintenance activities, and troubleshooting in compliance with laboratory best practices

Benefits

• We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team.
• We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level