Scientist 3, Immunology

Genentech • Daly City, CA

9h

About The Position

The Position
We advance science so that we all have more time with the people we love.
The Opportunity
The Pappu Lab in the Department of Immunology at Genentech is seeking a highly talented, driven and motivated Scientist 3 to investigate novel biological mechanisms and potential therapeutic targets to treat inflammatory diseases. The successful candidate will lead projects that advance our understanding of the cellular and molecular mechanisms of adaptive and innate immunity, with a main emphasis on harnessing immunoregulatory mechanisms for reestablishing immune and tissue homeostasis under inflammatory conditions.
The candidate will be expected to work independently and collaboratively on pipeline projects and will be responsible for advancing exciting and novel research stage programs into early clinical development, providing both scientific and technical expertise and generating solid proof of concept data. Prior industry experience is required, particularly in target discovery. Excellent communication skills, will facilitate fruitful and open collaborations with other labs in immunology, regenerative medicine, human genetics, biomarker discovery and early clinical development. Time and space will be provided to drive both pipeline research and also explore new biologies and pathways for new target discovery. Using state of the art techniques and technologies, the candidate will have the capacity to develop in vitro and in vivo skills to test the involvement of novel pathways and molecules in the pathogenesis of inflammatory diseases and to identify the mechanism of action (MOA) of new targets.

Requirements

• PhD degree in immunology, molecular biology, biochemistry or a related field with a demonstrated record of professional achievement in the form of high-quality publications.
• Experience in target discovery within industry research setting
• Extensive hands-on experience in cellular and molecular immunology techniques including primary cell isolation from tissues, in vitro immunological assays, multi-dimensional flow cytometry and in vivo animal models.
• Independently designing, executing and interpreting experiments.
• Have excellent communication skills and willingness to work in a collaborative environment and core lab.
• Can present research at intra- and inter-departmental meetings.

Nice To Haves

• A strong background in adaptive and innate immunity is highly desirable.
• Experience with state-of-the-art precision genome editing technologies and their application for cell engineering is of interest.
• Experience with analysis of data from genomic sequencing, scRNA-seq, TCR-seq, CITE-seq or spatial transcriptomics is a plus.
• Experience with in vivo immunological experimental techniques

Responsibilities

• Lead projects that advance our understanding of the cellular and molecular mechanisms of adaptive and innate immunity
• Harness immunoregulatory mechanisms for reestablishing immune and tissue homeostasis under inflammatory conditions
• Work independently and collaboratively on pipeline projects
• Advance exciting and novel research stage programs into early clinical development
• Provide both scientific and technical expertise and generating solid proof of concept data
• Drive both pipeline research and also explore new biologies and pathways for new target discovery
• Develop in vitro and in vivo skills to test the involvement of novel pathways and molecules in the pathogenesis of inflammatory diseases and to identify the mechanism of action (MOA) of new targets

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree