Scientist, Early Stage Formulation

AstraZeneca•Gaithersburg, MD

1d•Onsite

About The Position

Scientist, Early Stage Formulation Sciences Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. About AstraZeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the group: The Biopharmaceutical Development (BPD) group is a multi-disciplinary scientific function providing expertise in Process/Analytical/Formulation/Device Development and Characterization with integrated Bioprocess Engineering, Clinical Manufacturing, and Supply Chain and Logistics operations. The group is also responsible for transferring the processes to different clinical and commercial sites in and outside the AstraZeneca organization. BPD group is present in multiple sites in US and UK. This position is in Early Stage Formulation Sciences within BPD, responsible for designing and developing formulation and Drug Product presentations from pre-clinical through Phase 3 clinical trials and in support of commercialization.

Requirements

M.S. in Chemical/biochemical engineering, Chemistry, Biochemistry, Pharmaceutical Sciences or related field with a minimum of 2 years of relevant industry experience.
Experience with formulation development, biophysical characterization, and stability testing of proteins
Science oriented, highly motivated self-starter with drive to succeed
Meticulous in execution of laboratory experiments and reporting
Good communication skills, strong interpersonal skills, and ability to thrive in an interdisciplinary fast paced environment

Nice To Haves

Knowledge of stability and rheological properties of high concentration biologics formulations
Knowledge of antibody formulation liabilities, formulation interactions, and desired properties like binding, stability, and developability
Familiarity with antibody structure, different antibody modalities including multi-specifics and antibody-conjugates, and degradation mechanisms
Familiarity with different routes of administration (intravenous, subcutaneous), delivery devices, and combination products
Knowledge of Design of Experiments and statistical principles
Ability to work effectively as an individual contributor and as a team member within a matrix environment.

Responsibilities

Perform research in state-of-the-art laboratories that are focused on formulation and process development of biologics
Evaluate protein formulation development, characterization, and stability testing
Contribute to advancing AstraZeneca's pipeline of diverse antibody modalities
Drive innovation across a variety of scientific domains
Make in-depth experimental observations, analyze and interpret experimental results, and present scientific data
Act as Functional representative on CMC teams
Author CMC sections for regulatory filings