Scientist I or II - Peptide Chemistry

UCB • Cambridge, MA

1d • Hybrid

About The Position

We are seeking a motivated new PhD or experienced BS/MS scientist to be an integral member of the Cambridge, MA Chemistry group as a Scientist I or II – Peptide Chemistry, responsible for using our powerful mRNA display peptide discovery platform to identify and engineer novel ligands of target proteins that are implicated in human diseases with unmet medical needs. The lab-based position will be part of our peptide chemistry group. The scientist will work closely with medicinal chemistry and DNA encoded library groups to develop new synthesis and screening technologies on and off beads. The successful candidate will be a skilled experimentalist with deep knowledge of peptide chemistry and synthesis.
Responsibilities:
Synthesize polypeptides with automated peptide synthesizers or manually. Workup, purify and deliver those peptides for biological assays. Design drug-like peptide molecules utilizing medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.
Design and synthesize peptide conjugates with other therapeutic agents.
Develop and implement new methods to advance our peptide drug discovery efforts.
Ensure optimal interaction, communication and provide regular updates on project status to the program leads and leadership team.
Participate in new target identification and validation
Triage screening hits, and carry out hit to lead
Learn to independently lead programs with the goal of delivering of drug candidates
Are you ready to ‘go beyond’ to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!
About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe, inspired by patients and driven by science.
Why work with us?
At UCB, we don’t just complete tasks, we create value. We aren’t afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We ‘go beyond’ to create value for our patients, and always with a human focus, whether that’s on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.
At UCB, we’ve embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.
UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on [e-mail]. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.

Requirements

• A recent Ph.D. or experienced BS/MS scientist in organic chemistry, chemical biology, medicinal chemistry, or related field.
• Proficient in peptide chemistry design, synthesis, purification, characterization, bioconjugation technologies.
• Deep knowledge and experiences in solid phase peptide synthesis
• Experience with chromatography and mass spectrometry data analysis, method development, and applications

Responsibilities

• Synthesize polypeptides with automated peptide synthesizers or manually.
• Workup, purify and deliver those peptides for biological assays.
• Design drug-like peptide molecules utilizing medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties.
• Design and synthesize peptide conjugates with other therapeutic agents.
• Develop and implement new methods to advance our peptide drug discovery efforts.
• Ensure optimal interaction, communication and provide regular updates on project status to the program leads and leadership team.
• Participate in new target identification and validation
• Triage screening hits, and carry out hit to lead
• Learn to independently lead programs with the goal of delivering of drug candidates

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree