Pioneering Medicines: Scientist, Invitro Pharmacology

Flagship Pioneering•Cambridge, MA

1d•$100,000 - $126,500

About The Position

What if… We could harness the power of Flagship’s breakthrough scientific platforms to create entirely new therapeutic modalities — and deliver transformative medicines to patients faster? Pioneering Medicines, a division of Flagship Pioneering, is building a premier biopharmaceutical R&D organization dedicated to conceiving and advancing life-changing therapies. By integrating and applying Flagship’s innovative platform technologies to serious diseases with high unmet need, we aim to redefine how medicines are discovered and developed. A defining strength of our approach is the ability to combine multiple platforms to generate truly novel and potentially transformative treatments . About Flagship Pioneering Flagship Pioneering is a life sciences innovation company that conceives, creates, resources, and develops first-in-category scientific ventures to transform human health and sustainability. Since its founding in 2000, Flagship has originated and fostered more than 100 scientific ventures , generating tens of billions in aggregate value and advancing breakthroughs across biotechnology and sustainability. Flagship’s unique hypothesis-driven innovation model has enabled the creation and growth of an ecosystem of 40+ companies — including high-impact ventures such as Moderna, Tessera Therapeutics, Generate:Biomedicines, Sana Biotechnology, Indigo Agriculture, and Inari — that span cutting-edge platform technologies and therapeutic modalities Position Summary Pioneering Medicines is seeking a scientifically rigorous, innovative, and collaborative Scientist to join our In Vitro Pharmacology team. This role is ideal for a PhD-trained scientist with industry experience who thrives at the intersection of in vitro pharmacology and translational science. The successful candidate will lead in vitro pharmacology efforts for one or more discovery programs, designing and executing critical experiments that inform candidate selection and go/no-go decisions. You will contribute to the evaluation of novel therapeutic modalities across multiple disease areas, including immunology, oncology, cardiovascular, and metabolic diseases. This role requires deep expertise in cell-based assay development, mechanistic biology, and translational thinking, along with the ability to operate in a fast-paced, highly collaborative environment.

Requirements

PhD in Biology, Pharmacology, Immunology, or a related discipline
2+ years of relevant industry experience in drug discovery (biotech or pharma preferred)
Demonstrated expertise in developing and implementing complex in vitro cell-based assays
Strong hands-on experience with mammalian cell culture, including primary human cells
Working knowledge of in vitro pharmacology principles (compound handling, dose-response analysis, potency/efficacy characterization)
Proficiency in data analysis tools
Strong experimental design, data interpretation, and scientific communication skills
Experience maintaining rigorous documentation in ELN systems

Nice To Haves

Industry experience advancing programs from target validation through IND-enabling studies
Research background in immunology, immuno-oncology, oncology, cardiovascular or metabolic disease
Familiarity with emerging therapeutic modalities (e.g., small molecules, peptides, biologics etc)
Track record of impactful scientific contributions, including publications, presentations, or advancement of therapeutic candidates
Experience managing collaborations with academic partners, biotech/pharma collaborators, or CROs

Responsibilities

Provide scientific leadership for in vitro biology and pharmacology activities on designated discovery programs
Design, develop, and optimize robust, physiologically relevant cell-based assays to evaluate potency, efficacy, mechanism of action, and differentiation of candidate therapeutics
Develop and execute assays using cell lines, human primary cells, peripheral blood cells, and complex ex vivo systems to support translational strategy
Drive experimental strategy to rapidly generate decision-enabling data and advance programs toward development milestones
Collaborate closely with in vivo, translational, platform, and CMC teams to ensure alignment from early discovery through clinical development
Partner with external collaborators and CROs to design, oversee, and interpret in vitro studies
Contribute to scientific strategy discussions and present findings to cross-functional stakeholders and leadership
Mentor and guide junior scientists as appropriate