Scientist – Molecular Biology & Pharmacology

Amgen • South San Francisco, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist – Molecular Biology & Pharmacology What you will do Let’s do this. Let’s change the world. In this vital role you will be responsible for designing, developing, and optimizing assays to identify and validate potential drug candidates, including developing and executing primary cell and whole blood assays. The successful candidate should possess strong technical expertise & laboratory skills, have excellent written and oral communication skills, work productively in a collaborative cross-functional team environment, and keep current with field of expertise, including literature and technology development.

Requirements

• Doctorate degree OR Master’s degree and 2 years of Molecular Biology and Pharmacology experience OR Bachelor’s degree and 4 years of Molecular Biology and Pharmacology experience

Nice To Haves

• PhD in Immunology, Pharmacology, Cell Biology, Molecular Biology or a related field, with relevant postdoctoral experience preferred
• Expertise in quantitative pharmacology, Cytokine secretion and Phosphorylation assay
• Mastery in isolating various primary cells such as different types of T and B cells
• A deep and broad understanding of the development, validation & execution of a wide array of cell-based assays such as cytokine secretion, cell migration, etc.
• Demonstrated ability to develop and implement cellular assays for target validation, hit identification, and lead optimization, such as MesoScale Discovery, HiBIT, NanoBRET, and cell reporter assays
• Familiarity with Luminex Multiplex assay, and proficiency in Flow Cytometry
• Highly skilled in the development & implementation of robust, automated, 384 or 1536-well plate-based assays using a wide range of detection methods (e.g., spectrophotometry, radiometry, luminescence, fluorescence)
• Experience with microplate readers and automated liquid handling systems (e.g., PerkinElmer Envision, Labcyte Echo, Agilent Bravo, etc.)
• Experience with data analysis and visualization software platforms (e.g., Genedata Screener, Tibco Spotfire, GraphPad Prism, etc.)
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment

Responsibilities

• Develop and optimize Primary cell-based assays to support HTS, hits validation, and lead optimization for novel therapeutic targets
• Develop and execute cell-based assays to assess the effects of small molecules on cellular pathways, receptor activity, and phenotypic outcomes
• Evaluate and implement new technologies to enhance screen capabilities and assay performance
• Stay current with scientific literature and industry trends related to assay technologies, novel drug modalities, and drug discovery
• Represent department in multi-disciplinary project teams to present research results and provide scientific and technical support
• Collaborate with internal cross-functional teams and external partners to enable project progression

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree