Scientist, Upstream Bio Process

MSD • Upper Gwynedd Township, PA

1d • Hybrid

About The Position

Scientist/Engineer – Upstream Vaccines and Advanced Biotechnologies Process R&D Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork. As part of our global team, you will have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. Applications are sought for an opportunity in the Vaccine and Advanced Biotechnologies Process R&D department (VaxPRD), which is part of the our company's Research Labs division. The individual will support our company's discovery & development efforts for Vaccine programs at West Point, PA. Vaccine Process Development Scientist/Engineer Role Summary Vaccines and Advanced Biotechnologies Process R&D (VaxPRD) is responsible for the development and clinical manufacturing of Drug Substance (DS) and Drug Product Intermediates (DPI) for the vaccine and advanced therapy pipeline, spanning from preclinical to commercialization stages. We are part of the Process R&D organization, which enables modality-agnostic DS/DPI process development and clinical manufacturing for our company's pipeline. Our vaccines upstream process development team develops safe, scalable, robust, cost-effective upstream processes that enable clinical and commercial manufacture of vaccines and adjuvants across all vaccine modalities. Under the direction of the group leader, the individual will be responsible for upstream process development of vaccine candidates. The successful candidate will plan, perform, and critically evaluate lab scale process development and scale-up studies, develop robust, efficient, scalable processes for vaccine production, and support transfer of processes to clinical or commercial manufacturing facilities. The individual is expected to function in a multidisciplinary environment, contributing subject matter expertise to teams engaged in development and clinical manufacture of vaccine candidates. This position requires the employee to be willing to work with infectious agents and/or pathogens and may require occasional travel and off-hour/weekend work.

Requirements

• Must have a BS or MS in a relevant field such as: Engineering: Chemical Engineering, Bioengineering, Biomedical Engineering Science and Technology: Biological Sciences, Biochemistry, Biotechnology, Cell Biology
• For BS: at least two (2) years of post‑graduate experience in a bioprocess/biotechnology related position
• For MS: at least one (1) year of post‑graduate experience in a bioprocess/biotechnology related position or relevant academic research thesis.
• Strong scientific understanding of fermentation and cell culture processes, with hands-on experience in bioprocess development.
• Excellent scientific understanding of cell biology relevant to vaccine production, including cell metabolism and molecular biology.
• Demonstrated proficiency with bench scale bioreactors, shake flasks, or other cell propagation systems for optimization of cell culture or fermentation processes.
• Demonstrated ability to perform quantitative data analysis (e.g., statistical analysis of experimental data using software tools for data handling and visualization).
• Ability to work independently and as part of a team; strong self-motivation, adaptability, and a positive attitude.
• Ability to learn new techniques, balance multiple projects, keep accurate records, follow instructions, and comply with company policies.
• Excellent organization, interpersonal, verbal, and written communication skills.
• Willingness to work with infectious agents and/or pathogens.
• Willingness to travel occasionally and to work off-hours/weekends as needed to support operations or technology transfer.

Nice To Haves

• Experience with vaccines and/or therapeutic proteins
• Experience with data science and modeling tools (e.g., statistics, design of experiments, and/or coding/scripting such as Python or similar tools for data analysis and modeling).
• Prior experience with lab scale (10 L–200 L) CIP/SIP stainless steel bioreactors.
• Prior experience in optimizing recombinant protein expression (quality and quantity of product).
• Prior experience with fermentation bioprocesses (e.g., E. coli, yeast).
• Direct experience with upstream bioprocess unit operations (e.g., cell culture, bioreactors, centrifugation, filtration, in process analytics) in and industrial environment.
• Prior experience with the application of PAT for monitoring upstream bioprocesses
• Prior experience with the application systems biology approaches (e.g., “-omics”) to increase process understanding and/or solve upstream bioprocess challenges
• Sound understanding of process scale-up principles

Responsibilities

• Design, execute, and analyze process development experiments to maximize understanding of cell culture and fermentation processes to enable robust vaccine manufacturing.
• Conduct laboratory bench work to execute, optimize, and troubleshoot cell culture and fermentation processes (e.g., shake flasks, bench scale and pilot scale bioreactors).
• Apply data analysis and basic data science/modeling approaches (e.g., statistics, design of experiments) to design experiments, interpret datasets, and support process understanding and optimization.
• Contribute to the development and scale‑up of upstream processes from lab scale to pilot scale and support technology transfer to manufacturing scale.
• Perform upstream unit operations as needed, including lab scale cell culture, fermentation, centrifugation, filtration, and in-process assays.
• Maintain and coordinate raw material and equipment inventories; ensure equipment is operated and maintained in a safe, compliant manner.
• Prepare clear technical reports and presentations to summarize and communicate experimental results and recommendations in a collaborative team environment.
• Mentor and provide technical guidance to contract staff or new hires in laboratory techniques and best practices, as appropriate.
• Keep accurate, detailed laboratory records; comply with all required training and maintain a strong focus on laboratory/facility safety for self and team members.

Benefits

• We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level