Scientist

Arcellx • Rockville, MD

9d • $105,000 - $125,000 • Onsite

About The Position

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members are made up of talented innovators and dreamers working from our offices in Rockville, Maryland, and Redwood City, California. At Arcellx, we hire exceptional people and create a fun, diverse, supportive, and informal environment that allows everyone to do their best work. As a Scientist within our Cell Biology group, you will have a direct impact our drug pipeline as a lab-based contributor and functional area lead within the project setting . Our potentially life- saving treatments would not exist without the work of our talented scientists. Your work as a member of our experienced cross-functional team will drive discovery, characterization, and optimization of novel cell-based therapies .

Requirements

• Candidates with a master’s degree and 4 - 6 + years research experience within the pharmaceutical industry or a PhD-level scientist from a relevant field and 0-2 years industry experience.
• Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion , and cryopreservation.
• Familiarity with markers of memory, exhaustion, and activation for phenotyping of CAR-T cells by flow cytom e try.
• Expertise in immune cell assays including multiparameter flow cytometry, in vitro cell based assays ( e.g. cytotoxicity, proliferation, degranulation), live cell analysis ( IncuCyte ) , cytokine measurement (ELISA or Lumit ), and multiplex assays.
• Expertise in p seudotyped lentivirus generation by transient transfection .
• Expertise in basic cell line manipulation, including transient transfection, CRISPR knockout, antigen overexpression, and single cell cloning .
• Expertise in basic molecular biology techniques, including genomic DNA extraction and qPCR for vector copy number measurement .
• Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents.
• Familiarity with in vivo models of human cancer, including cell line derived xenografts or patient-derived xenografts.
• Effective and timely communication of results and relevant scientific literature.
• Proficient in common software, including GraphPad Prism, Word, PowerPoint, Excel, Outlook, SnapGene , and FlowJo , for data analysis, documentation, and presentation .
• Ability and desire to multitask and function in a fast-paced entrepreneurial environment.
• Interpersonal skills that promote a collaborative and productive lab environment.
• Effective and efficient written and oral communication skills .

Nice To Haves

• Specific backgrounds of interest are:
• Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics
• Other Immuno- modulatory drug modalities (T-cell engagers or multi-specific proteins)
• Autoimmune diseases research ( E merging therap ies , p athogenic mechanisms, immune tolerance & reset, signaling pathway s )
• Preferably experience on BD instruments or Cytek Aurora for flow cytometry.

Responsibilities

• Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions.
• Design and execute experiments independently with minimal supervision , as well as effectively plan and organize work activities and prioritize task completion.
• Serve as a functional area lead within a project setting ; helping to derive timeline s, plan, and execute to help achieve project goals .
• Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies.
• Communicate detailed observations on experiments and assist in the preparation of technical reports, summaries, and protocols .
• Commitment to ethical scientific investigations and rigorous experimental methods .

Benefits

• Our market-leading benefits package includes: 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 101-250 employees