Senior Computational Scientist, Translational Sciences, Immunology

Johnson & Johnson Innovative Medicine • Spring House, PA

1d • Hybrid

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine About Immunology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine Translational Immunomics, Johnson & Johnson Innovative Medicine uses multidimensional multimodal data (including transcriptomics, genetics and proteomics) to support portfolio projects and to develop precision medicine approaches within the Immunology Therapeutic Area. The successful candidate will contribute to the computational biology for Immuno-Dermatology programs and will be effective in the use of relevant computational tools (in R and Python, including Graphia workflows). They will be able to deliver timely and comprehensive analysis and interpretation of high-dimensional biological data across all aspects of portfolio development and have hands-on experience with analysis of clinical trial biomarker data. The Senior Scientist will serve as a computational biology analyst in the Immuno-Dermatology area and will be accountable for analytical and platform support for clinical trial data, development of molecular understanding of human inflammatory skin disease, as well as deriving impactful insights and communicating resulting findings to key stakeholders to improve understanding of the disease biology and the structure of patient populations. We are looking for a knowledgeable, motivated and collaborative computational biologist with a passion for precision medicine and tailoring therapy to patients for better outcome. Most importantly, we seek someone who shares our belief that human molecular data holds the key to developing better pharmaceutical strategies that will transform the lives of patients. The holder of this position will be mentored by a highly qualified computational biology leader, with experience both in the industry and academia, and will be embedded in a team of computational biology researchers, including bioinformaticians, computer scientists, and omics platform developers. As part of Translational Sciences in Immunology, the scientist will interact with clinical, experimental and leadership teams across the Immuno-Dermatology area. Ongoing collaborations will provide an opportunity to interact with key opinion leaders in dermatology. The position offers opportunities to develop leadership skills in a highly productive industrial environment.

Requirements

• A PhD degree in a relevant field, related to use of computational or statistical analysis to decipher biology from high dimensional data, including computational biology, computational immunology, bioinformatics, or a related field + 3-5 years of relevant post-doctoral experience
• Proficiency in standard coding-based analytical platforms (e.g., R, Python, etc.)
• Documented ability of hand on experience with support to clinical trials in immunoDermatology
• Experience in analyzing high-throughput proteomic platforms (OLINK) data and building Co-expression Networks using Graphia
• Academic/industrial experience using computational biology to discover clinical endotypes from molecular data
• Fluent in written and spoken English
• Outstanding communication and collaboration skills

Nice To Haves

• Experience in methodologies for data integration, network/pathway analysis, genomics, statistical modeling, machine learning methodologies and their application to molecular, clinical, pre-clinical and health outcomes data for identification of predictive biomarkers for patient stratification and precision medicine.
• Experience working within cross-function teams
• Experience in multi-omic computational analysis of large collaborative studies with external collaborators to stratify patients in the immunodermatology landscape.
• Experience in using AI tools (e.g. Autoencoder) for annotation of single cell and/or spatial data
• Industry and/or translational research experience is highly preferred.

Responsibilities

• Effective use of relevant computational tools to deliver analyses of high-dimensional biological ('omics) data to support all aspects of portfolio development in immuno-dermatology
• Coordinating and delivering computational support across portfolio programs
• Design and execution of data analysis, interpretation of results, documentation and generation of analysis reports
• Analytical support for multi-omics collaborative projects
• Deriving impactful insights and communicating findings to key stakeholders to improve understanding of inflammatory skin disease biology and patient heterogeneity
• Accurate documentation of developed methodology and results, for internal dissemination and high-quality publications
• Project Leadership s with internal groups/external collaborators

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree