Senior Manufacturing Systems Engineer

Amgen • Holly Springs, NC

3d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Manufacturing Systems Engineer What you will do Let’s do this. Let’s change the world. In this vital role, you will serve as the technical authority and site owner for the DeltaV platform at Amgen’s North Carolina manufacturing site. You are accountable for the platform’s architecture, lifecycle strategy, compliance posture, reliability, and long-term sustainability in alignment with enterprise standards. This role enables plant engineering and operations to deliver compliant, reliable manufacturing through resilient and well-governed platform services. This role is explicitly site-specific: you will not own plant equipment or enterprise-wide DeltaV governance, though you will coordinate and align with enterprise standards, service owners, and vendors.

Requirements

• Doctorate degree OR Master’s degree and 2 years of Information Systems, Engineering and/or Information Technology experience OR Bachelor’s degree and 4 years of Information Systems, Engineering and/or Information Technology experience OR Associate’s degree and 8 years of Information Systems, Engineering and/or Information Technology experience OR High school diploma / GED and 10 years of Information Systems, Engineering and/or Information Technology experience

Nice To Haves

• 5+ years of experience supporting or owning manufacturing automation or control system platforms in a regulated environment (e.g., Emerson DeltaV, Rockwell FactoryTalk, Siemens BAS, or similar DCS/PLC-based platforms), including system-level administration and architecture.
• Experience operating within GMP-regulated manufacturing environments, including validation lifecycle (IQ/OQ/PQ) and change control governance.
• Experience with industrial platform infrastructure including networking (Ethernet-based I/O), virtualization, Windows Server environments, Active Directory integration, backup/disaster recovery, and patch management.
• Practical experience integrating automation platforms with MES, historians (e.g., OSI PI), and enterprise systems using OPC, web services, REST APIs, or middleware technologies.
• Experience supporting 24x7 manufacturing-critical systems with defined SLOs, monitoring/observability frameworks, and structured incident management.
• Familiarity with industrial control system (ICS) cybersecurity principles including network segmentation, secure remote access, and privileged account management.
• Demonstrated ability to translate enterprise standards into site-level implementations and lead cross-functional platform governance discussions.

Responsibilities

• Define, evolve, and document the North Carolina site DeltaV platform architecture (controllers, servers, HMI, virtualization, redundancy, and network topology) and develop a site-level roadmap aligned with enterprise direction.
• Serve as the site decision authority for DeltaV platform changes, lifecycle prioritization, and risk acceptance in coordination with enterprise stakeholders.
• Own and execute lifecycle operations strategy including provisioning, capacity planning, patching, upgrades, license management, and disaster recovery to ensure high availability manufacturing while minimizing production risk.
• Establish and maintain a robust platform CMDB and asset inventory to ensure configuration integrity and audit readiness.
• Govern and implement site-level DeltaV integrations with MES, OSI PI, Active Directory, and other enterprise systems.
• Define site service level objectives (SLOs) for the DeltaV platform; implement monitoring, telemetry, alerting, and incident response processes, and drive root-cause analysis and continuous reliability improvement.
• Own the site-level DeltaV validation approach, including development of platform validation artifacts (IQ/OQ/PQ) and audit support.
• Implement and enforce ICS security controls (network segmentation, secure remote access, privileged access management) in partnership with corporate cybersecurity and site network teams.
• Effectively manage relationships with technology service owners, business partners, enterprise service partners, and vendors.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior