Senior Research Associate/Associate Scientist

Xaira Therapeutics • South San Francisco, CA

9d • $110,000 - $125,000

About The Position

As a part of the Protein Analytics team, you will play a crucial role in discovering and developing novel biotherapeutics. The ideal candidate will have extensive experience characterization of monoclonal and bi/multispecific antibodies within a biotherapeutics discovery setting, coupled with a proactive and can-do attitude. This is a hands-on, lab-based position.

Requirements

• BS/MS degree with 4+ years of industry experience in biochemistry, biophysics, biochemistry, structural biology, or a related discipline, OR a PhD degree in similar disciplines with 2+ years of industry experience.
• Extensive experience in antibody screening including monoclonals, bispecific, and other antibody-like molecules.
• Extensive hands-on experience with ELISA, BLI and SPR based platforms.
• Basic knowledge of protein production, purification and characterization techniques (including affinity, ion exchange, HIC, DLS, DSF and SEC).
• Proficiency in data analysis software (e.g., GraphPad Prism) and other statistical tools.
• Proactive attitude with a self-starter mindset.
• Strong organizational, communication, and interpersonal skills.
• Strong collaborative skills and interest in working in cross-functional teams and a startup environment.
• Excellent problem-solving and troubleshooting abilities.
• Ability to work independently with accountability and meticulous attention to detail.

Responsibilities

• Support the discovery and development of therapeutic molecules through hands-on laboratory work.
• Characterize antibodies in high-throughput manner via biolayer interferometry (BLI) and surface plasmon resonance (SPR) based biosensor platforms to determine Yes/No binding, Kinetics and Affinity information.
• Screen antibodies and other antibody-like molecules for off-target binding test via BVP ELISA or other poly-specificity/poly-reactivity assays.
• Perform developability assessment on antibody panels using SPR, DLS, DSF, SEC and ELISA platforms.
• Analyze experimental data, curate results and reports, and present findings to cross-functional teams.
• Maintain experimental records in an ELN.
• Support other workflows as needed, including expression and purification, binder discovery and other functional assays.
• Ensure compliance with laboratory safety protocols and contribute to lab organization and operations.

Benefits

• We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers.
• A Summary of Benefits is available for all applicants.
• We offer a competitive package that includes base salary, bonus, and equity.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level