Senior Research Associate, Beta Islet Differentiation

Century Therapeutics•Watertown, MA

13h

About The Position

Century Therapeutics (NASDAQ: IPSC) is a biotechnology company advancing a pipeline of induced pluripotent stem cell (iPSC)-derived cell therapies with the potential to meaningfully address autoimmune diseases, including type 1 diabetes, and cancer. The company’s therapies are derived from its iPSC cell foundry and leverage its novel immune evasion engineering technology, Allo-Evasion™. Century believes its approach to developing off-the-shelf cell therapies will expand patient access and provide advantages over existing cell therapies which will ultimately advance the course of care. Role: Century Therapeutics is seeking a highly motivated Senior Research Associate to join our Beta Islet Differentiation team. In this role, you will contribute to the development of our T1D CNTY-813 cell therapy by executing and optimizing differentiation of induced pluripotent stem cells (iPSCs) into functional beta islets. You will play a key role in refining differentiation protocols and driving analytical characterization of cell populations, with a strong emphasis on flow cytometry, qPCR, and ELISA-based readouts. This position is ideal for someone with hands-on experience in stem cell biology who enjoys experimental optimization, data generation, and assay execution in a fast-paced environment.

Requirements

BS or MS degree in a relevant biological field with 2–6+ years of industry experience.
Hands-on experience with iPSC culture and differentiation (beta islet experience strongly preferred).
Strong experience with flow cytometry, including intracellular staining and data analysis (e.g., FlowJo).
Strong experience with qPCR, including assay setup and data interpretation.
Experience with ELISA or other functional assays.
Strong data analysis and experimental troubleshooting skills.
Excellent documentation and organizational skills.
Ability to work independently while contributing to a collaborative team environment.
Strong communication skills and attention to detail.
Experience working with stem cell-derived islet differentiation.
Experience with suspension culture differentiation formats.
Experience with multi-color intracellular flow cytometry.
Experience with assay development.

Responsibilities

Perform routine culture, maintenance, and differentiation of human induced pluripotent stem cells (iPSCs).
Design and execute experiments to optimize beta islet differentiation protocols for improved efficiency, reproducibility, and cell quality.
Conduct analytical characterization of differentiated cell populations, including: Multi-color intracellular flow cytometry for phenotypic profiling, quantitative PCR (qPCR) for gene expression analysis, and ELISA for functional assessment.
Analyze and interpret experimental data, generating clear and reproducible datasets to support program advancement.
Maintain accurate and detailed experimental records in electronic lab notebooks.
Present data and contribute to scientific discussions within the team.
Support lab operations, including inventory management, reagent tracking, and ordering of materials.
Draft, review, and update experimental protocols and standard operating procedures (SOPs).
Ensure adherence to established protocols and quality standards.
Collaborate effectively with team members to support CNTY-813 program goals.