Senior Research Associate, Drug Product
About The Position
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We have an opening for a full-time position as a Senior Research Associate position within the Drug Product function of our Pharmaceutical Development and Manufacturing (PDM) department. The position will be laboratory-based and responsible for preformulation studies, preclinical formulations development, and troubleshooting to support Revolution Medicines’ drug product development.
Requirements
- BS with minimum 5 years or MS with minimum 3 years of the relevant laboratory experience in pre-formulation, formulation development, solid form screening, and analytical development.
- Proficient in laboratory analytical techniques, specifically in HPLC, NMR, PXRD, PLM, DSC, TGA, DVS, and PSD measurements.
- Experience in preclinical formulation screening and development to support in-house formulation preparations and management.
- Good understanding of basic organic chemistry and analytical chemistry.
- Excellent communication skills and a collaborative team player.
- Highly organized with strong attention to detail and documentation skills.
- Ability to multi-task and thrive in a fast-paced innovative environment.
Nice To Haves
- BS and/or MS degree in pharmaceutical sciences, chemistry, and chemical engineering, or related discipline.
- HPLC method development experience is preferred.
Responsibilities
- Conduct solution and solid-state preformulation studies for RevMed research and development candidates (i.e. solubility, dissolution, excipient compatibility, stability studies, permeability and biopharmaceutics assessment, mechanical and processing properties).
- Conduct solid form related activities of new chemical entities during preclinical assessment and throughout the clinical development phases (ie. solid form screening, co-crystal and salt screening, solid form identification, and solid-state characterization).
- Support preclinical and (if needed) clinical formulation development.
- Collaborate with Research team and prepare preclinical formulations in a timely manner.
- Analyze formulations using suitable analytical methods to assess formulation stability, and dose analysis.
- Maintain good laboratory notebook record (i.e. ELN) to document formulation preparation process, test results, and lab activities.
- Help to maintain and manage lab activities, such as chemical inventories, calibrations, safety practices, new equipment acquisition, installation, and training.
- Conduct lab activities for troubleshooting formulation and solid form related issues.
- Write, revise, and update formulation protocols in a timely manner; support efforts to maintain and organize formulation protocols.
- Provide support to research and PDM organizations for requests related to API and formulations.
- Work closely with immediate supervisor on problems that may be of moderate complexity.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
