Senior Research Associate, Oligonucleotide Chemistry

Tessera Therapeutics • Somerville, MA

1d

About The Position

Your experience includes… BS/MS in Chemistry, Biochemistry, Chemical Engineering, or related field with 5+ years (BS) or 3+ years (MS) of relevant industry experience Excellent knowledge and thorough understanding of upstream and downstream processing of oligonucleotides Experience with enzymatic ligation and HPLC purification of oligonucleotides Experience using Agilent and Waters analytical instruments for purity analysis Detail and results oriented with experience using ELNs to document experiments and results It’s a bonus if you have experience working in a cGMP environment You are interested in… Developing and implementing strategies for enzymatic ligation and purification of complex oligonucleotides Optimizing chemical reactions and purification methods to ensure scalable and cost-effective manufacturing processes for oligonucleotides Supporting process scale-up and transition into a cGMP-compliant manufacturing environment Participate in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing About you: You are a skilled and self-motivated individual who can optimize and implement processes for synthesizing and purifying complex oligonucleotides. You can operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team. You will have the opportunity to organize and present results within the group and interface with other teams, so strong communication skills are critical. You enjoy overcoming challenges in collaboration with colleagues. Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

Requirements

• BS/MS in Chemistry, Biochemistry, Chemical Engineering, or related field with 5+ years (BS) or 3+ years (MS) of relevant industry experience
• Excellent knowledge and thorough understanding of upstream and downstream processing of oligonucleotides
• Experience with enzymatic ligation and HPLC purification of oligonucleotides
• Experience using Agilent and Waters analytical instruments for purity analysis
• Detail and results oriented with experience using ELNs to document experiments and results
• Strong communication skills

Nice To Haves

• Experience working in a cGMP environment

Responsibilities

• Developing and implementing strategies for enzymatic ligation and purification of complex oligonucleotides
• Optimizing chemical reactions and purification methods to ensure scalable and cost-effective manufacturing processes for oligonucleotides
• Supporting process scale-up and transition into a cGMP-compliant manufacturing environment
• Participate in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing
• Optimize and implement processes for synthesizing and purifying complex oligonucleotides.
• Operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team.
• Organize and present results within the group and interface with other teams

Benefits

• group medical, vision, and dental coverage
• group life and disability insurance
• a 401(k) plan with company contribution
• tuition reimbursement
• annual incentive bonus
• equity grants

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level