Senior Scientist, Cell and Molecular Biology, Gene Editing

Editas Medicine • Cambridge, MA

1d • $150,000 - $165,000

About The Position

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Why Choose Editas? At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor! Decoding The Role: Editas Medicine is seeking an accomplished and highly-motivated Senior Scientist to join our Molecular and Cell Biology group. This individual will leverage their expertise in molecular and cell biology to test and optimize various gene editing strategies, develop and implement molecular and biochemical quantitative assays, and conceptualize and build in cellulo and in vivo disease models to advance novel CRISPR-based therapeutics. The Senior Scientist will play a key role in expanding Editas’s drug development pipeline and evolving the next generation of gene editing platforms.

Requirements

• Ph.D. in cell and molecular biology or a related field with 6+ years of industry experience (excluding post doc), or M.S. in cell and molecular biology with 8+ years of industry experience, or B.S. in cell and molecular biology or a related field with minimum 10+ years of industry experience.
• Experience working with CRISPR-based gene editing technologies and gene therapy modalities including lipid nanoparticles (LNP), RNA, and viral vectors (i.e. AAV, lentivirus).
• Extensive molecular biology expertise including plasmid and primer design, molecular cloning techniques such as Gibson assembly, restriction cloning, Quickchange mutagenesis, PCR and gel electrophoresis, DNA and RNA purification, in vitro transcription, LNP formulation, DNA quantification assays (i.e. qPCR, ddPCR), RNA quantification assays (RT-qPCR, RT-ddPCR), and protein quantification assays (e.g. JESS-Western Blot, ELISA, etc.).
• Extensive cellular biology experience including mammalian cell culture, DNA (e.g. plasmid) and RNA (mRNA, siRNA) transfections, small molecule treatments, immunocytochemistry or immunofluorescence, flow cytometry, and various cell-based assays to measure metabolites or enzymatic activity.

Nice To Haves

• Knowledge in genetic diseases, precision gene editing technologies, and gene therapy.
• Experience in protein structure-function studies, high-throughput mutagenesis screening, rational protein engineering, and directed evolution.
• An ability to drive success in a fast-paced, team-oriented, multidisciplinary environment, collaborate cross-functionally, and manage multiple projects in parallel while adhering to aggressive program timelines

Responsibilities

• Function within a team dedicated to developing new and innovative gene editing-based therapeutics from conception to IND-enabling studies, with a focus on innovating gene editing platform technologies.
• Work both independently and as part of cross-functional collaborations to design and execute critical experiments, generate, analyze, interpret, and communicate unambiguous data, or establish new scientific methodologies required for advancing program development in a timely manner.
• Engineer and evolve CRISPR-derived precision gene editing platform technologies via rational and/or combinatorial design workflows for optimizing therapeutic strategies.
• Develop in vitro or cell-based high-throughput screening methods for functional readout.
• Generate cell-based phenotypic models of diseases-of-interest and establish experimental paradigms to assess therapeutic hypotheses.
• Build quantitative assays to measure efficacy and biological function of gene editing strategies and impact on disease phenotypes in cell culture or in vivo models.
• Conceptualize and generate necessary molecular tools and reagents for testing gene therapies such as viral and non-viral delivery vectors (e.g. AAV, LNP, mRNA, plasmid).

Benefits

• Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree