Senior Scientist, Discovery BioSciences Oncology

Bristol Myers Squibb

5d • Onsite

About The Position

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Overview: We are seeking a highly motivated, experienced and talented Senior Scientist to join our Discovery Biosciences team. This individual will play a key role in advancing our oncology drug discovery programs, with a focus on cancer immunology and next-generation biotherapeutic target identification, validation, mechanism of action and optimization studies. This position is heavily focused on wet lab work, contributing to cutting-edge research projects aimed at understanding cancer biology, identifying novel drug targets, and developing new therapeutic approaches. The successful candidate will bring deep scientific expertise, creative problem-solving skills and a collaborative mindset to drive impactful research.

Requirements

• Bachelor’s Degree 7+ years of academic and / or industry experience
• Or Master’s Degree 5+ years of academic and / or industry experience
• Or Ph.D. or equivalent advanced degree in the Life Sciences 2+ years of academic and / or industry experience

Nice To Haves

• PhD and 2+ years of academic and / or industry experience preferred
• Extensive experience in oncology research, with background in cancer immunology and/or biotherapeutics (e.g. ADCs, multi-specifics, and TCEs) is strongly preferred
• Proven track record with designing and developing a variety of molecular biology and cellular assays
• Hands on experience with functional genomics, CRISPR screens, high content imaging, flow cytometry, RNA-seq and proteomics is highly desirable
• Proficiency in data analysis software (e.g., GraphPad Prism, FlowJo) and familiarity with bioinformatics tools
• Familiarity with querying large-scale oncology datasets (DepMap, cBioPortal, TCGA) to generate and test hypotheses
• Effective troubleshooting skills when optimizing assays and when developing innovative methodologies

Responsibilities

• Conduct full time laboratory-based research supporting target identification, oncology drug discovery and development
• Strong biology skills with experience using a wide range of cellular and molecular biology techniques, 2D and 3D cell culture and manipulation of complex cellular model systems (organoid, immune and stromal cell co-culture, and cancer cells), flow cytometry, qPCR, cell proliferation assays, generating reporter assays, molecular cloning, western blotting, immunoprecipitation, ELISA, and MSD
• Experience with in vivo oncology and/or immunology models. Animal handling is not a requirement, but the candidate should understand the strengths and weaknesses of commonly used cancer immunology models, and have experience with downstream tissue processing (dissociation, flow cytometry, IHC)
• Strong experience developing and applying state-of-the-art gene perturbation methods (siRNA/shRNA knockdown, nucleofection, and CRISPR-mediated genome editing)
• Design, optimize, and troubleshoot complex cell-based and in vivo assays to evaluate therapeutic candidates and understand cancer signaling pathways
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings
• Contribute to the preparation of technical reports, publications, and presentations

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level