Senior Scientist I, Clinical Biomarker Development

Revolution Medicines • Redwood City, CA

2d • Onsite

About The Position

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
Define and execute translational and biomarker strategies for Revolution Medicine’s clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
Manage external biomarker analysis at contract research organizations (CROs) including experimental design, fit-for-purpose validation, budgeting, timelines, oversight of clinical implementation, and data analysis during trial conduct.
Collaborate with Translational Medicine team members in biomarker operations and clinical bioinformatics on executing biomarker plans.
Evaluate new technologies to enable exploratory biomarkers.
Represent Translational Medicine within project/program teams; analyze, interpret, and present biomarker results, meet project/program milestones for TM responsibilities.
Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
Effectively collaborate across internal functions including translational sciences, clinical development, clinical operations, biostatistics, data management, and clinical pharmacology to ensure successful execution in the clinic.

Requirements

• Ph.D. or equivalent in Cancer Biology, Immunology, Cell/Molecular Biology or related.
• Employer will accept a Master’s degree or equivalent in Cancer Biology, Immunology, Cell/Molecular Biology or related and three (3) years of experience in biological data analysis in lieu of a Ph.D. or equivalent as described above.
• Academic coursework, internship or work experience to include:
• Analyzing biological data using Excel, GraphPad Prism, or equivalent tools;
• Hands-on experience with development and validation protocols of in vitro, in vivo, or clinical biomarker oncology assays;
• Managing and communicating with contract research organizations for biomarker testing and analysis (assay design, validation, testing conduct, timelines, data delivery);
• Experience preparing and presenting scientific presentations for internal meetings;
• Experience developing or analyzing data from methodologies such as next generation sequencing, ribonucleic acid sequencing (RNAseq), quantitative polymerase chain reaction (qPCR), immunohistochemistry, or multiplex immunofluorescence.

Responsibilities

• Define and execute translational and biomarker strategies for Revolution Medicine’s clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
• Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
• Manage external biomarker analysis at contract research organizations (CROs) including experimental design, fit-for-purpose validation, budgeting, timelines, oversight of clinical implementation, and data analysis during trial conduct.
• Collaborate with Translational Medicine team members in biomarker operations and clinical bioinformatics on executing biomarker plans.
• Evaluate new technologies to enable exploratory biomarkers.
• Represent Translational Medicine within project/program teams; analyze, interpret, and present biomarker results, meet project/program milestones for TM responsibilities.
• Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
• Effectively collaborate across internal functions including translational sciences, clinical development, clinical operations, biostatistics, data management, and clinical pharmacology to ensure successful execution in the clinic.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree