About the position
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. At Genentech and Roche, we're at the forefront of a revolutionary transformation in drug discovery powered by AI and machine learning. Our "lab in the loop" strategy processes massive quantities of experimental data to train AI models that accelerate the discovery of new medicines. To enable this vision, we're seeking exceptional Senior Software Development Engineers to be part of the team building and maintaining our next-generation Therapeutic Molecule Registration (TMR) platform - a foundational component of our AI-driven drug discovery infrastructure. This platform will serve as the central nervous system for managing and integrating molecular data across our global research organization, handling hundreds of billions of records and enabling unprecedented scale in virtual molecule design and testing. As the volume of AI-generated molecular designs grows exponentially, our TMR platform must evolve to become a high-performance, cloud-native system capable of supporting rapid iteration cycles between computational design and experimental validation. You will be instrumental in consolidating our molecule registration systems into a single, harmonized environment, unlocking the full potential of our data and accelerating the development of life-changing therapies.
Responsibilities
- Combine software engineering expertise with an interest in chemical and biological data management systems.
- Work closely with Genentech Computational Sciences (gCS) colleagues, including our machine learning for drug development team, Genentech Research & Early Development (gRED) Drug Discovery teams including the Antibody Engineering division, and other teams across the Roche family of companies to identify, strategize, and productionalize high-impact applications from across the drug discovery and development pipeline.
- Develop and maintain core features of our TMR platform.
- Write high-quality, testable code for chemical registration workflows.
- Design and implement RESTful APIs and microservices.
- Contribute to technical design discussions and architecture decisions.
Requirements
- Bachelor's degree in Computer Science or related field (or equivalent experience).
- 3+ years of software engineering experience.
- Strong Python programming skills.
- Basic Java/Kotlin knowledge.
- Experience with SQL databases.
- Understanding of REST APIs.
- Strong testing practices.
- Cloud platform exposure (preferably AWS).
Nice-to-haves
- Open source cheminformatics experience (e.g., RDKit, chemfp, Indigo, HELM toolkit).
- Chemical database cartridge expertise.
- Familiarity with biological sequence alignment.
- Chemical & biological structure notation expertise.
- Familiarity with chemical structure canonicalization.
- Molecular structure searching algorithm expertise.
- Experience with scientific software development.
- Familiarity with Docker and Kubernetes.
- Experience with event-driven architectures.
- Knowledge of security best practices.
Benefits
- Relocation benefits are available for this job posting.
- Discretionary annual bonus may be available based on individual and Company performance.
