Sr. Associate Scientist/Scientist - Downstream Process Development
About The Position
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. The Sr. Associate Scientist/Scientist is responsible for downstream protein purification, process development, and protein characterization. The position will directly report to a Downstream lead and assist in downstream process development and tech transfer to a GMP manufacturing facility. In this role, the individual will assist and operate both routine and advanced analytical instruments as well as protein purification systems. This position is full-time onsite at our Redmond, WA location.
Requirements
- PhD or MS in Protein Science, Chemical Engineering, Biochemistry or a related field
- 1+ years (PhD); 5+ years (MS); 7+ years (BS) of relevant pharmaceutical or biotech experience
- Demonstrate a good understanding of protein chromatography and filtration methods and protein analysis techniques.
- Ability to discuss experimental design and fully execute experiments independently from purification setup to analytical evaluation.
- Must-have experience with: ÄKTA Protein Purification Systems and Unicorn software SEC-HPLC/UPLC
- Hands-on experience in: Purification Process Development Crossflow and Tangential Flow Filtration techniques Column packing / unpacking Viral inactivation and viral filtration process development / Viral clearance study Low endotoxin production run Process scale-down/scale-up
Responsibilities
- Support drug candidate optimization, selection, validation, and stability study throughout pre-clinical and clinical downstream purification development for antibody/protein.
- Support and closely work with research, cell-line development, upstream, analytical and formulation groups.
- Design and develop scalable and robust purification processes via affinity chromatography, IEX, HIC and CHT, etc.
- Design and develop scalable and robust viral inactivation, viral filtration and tangential flow filtration process.
- Generate low endotoxin production runs for pre-clinical studies.
- Perform HPLC/UPLC, CE, cIEF, octet and other biophysical techniques to support upstream, downstream, and formulation process development.
- Perform and report interim analysis of accumulated data to monitor the safety of the drug or procedure.
- Establish relevant process transfer documents and cGMP documents to support successful implementation of process technology in clinical/commercial manufacturing operations including Standard Operating Procedures (SOP) draft and review.
- Prepare reports and papers of completed projects for publication in technical journals, patents, presentation to regulatory agencies or at conferences, or use in further research activities.
- Plan time to accommodate meetings and technical support with downstream and analytical team members in China-based R&D center.
- Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects.
- Other duties as assigned.
Benefits
- SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
- We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
- SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
