Sr. Director, Biotherapeutics

Manifold Bio•Boston, MA

13d

About The Position

Manifold Bio builds AI models for protein therapeutic design, trained on proprietary experimental data generated at unprecedented scale. Our in vivo-centric discovery platform produces millions of experimentally validated protein designs per campaign, creating the datasets that make our models possible and our approach uniquely powerful. We combine high-throughput protein engineering with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges. The Opportunity We are seeking an exceptional Senior Director of Biotherapeutics to help guide and mature Manifold's discovery, characterization, and production of shuttled therapeutics. This role spans discovery and nonclinical development, including optimal utilization of internal protein science expertise to run high-throughput in vivo screens, bioengineering strategies to generate best-in-class molecules, and oversight of external contract manufacturing organizations (CDMOs) to develop processes and manufacture drug product for clinical trials. As a key member of our leadership team, you will contribute to high-level strategy and help build internal resources to support our ambitious growth plans. This is a unique opportunity to shape the future of a cutting-edge biotechnology company while working with a collaborative, innovative team.

Requirements

Extensive experience in biotherapeutics across a range of protein modalities
Proven track record engineering antibodies for clinical development
Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
Deep knowledge of state-of-the-art protein engineering approaches, including display technologies
Experience with protein expression systems, purification methods, and characterization including developability assays
Prior experience liaising with CDMOs, particularly through IND
Understanding of assay development and typical strategies to select development candidates
Extensive experience leading both functional teams and matrix project teams
Strong mentorship and management skills with demonstrated ability to develop team members
Proven ability to balance diving into details while avoiding micromanagement
Track record of efficient execution and resource/budget planning
Demonstrated ownership and accountability in previous roles
Experience at smaller companies where leaders must directly drive execution and "roll up their sleeves"
Ability to clearly articulate core competencies and work effectively with external consultants
Easy to work with with a collaborative mindset
Brings joy and energy to work and inspires those around them
Humility and team-first approach; servant leadership style
Comfortable in fast-moving, agile organizations

Nice To Haves

Knowledge of neuroscience
Understanding of high-throughput screening or bioanalytical technologies
Experience with generative AI models for protein and/or oligonucleotide design

Responsibilities

Manage and mentor internal protein sciences and protein engineering teams
Foster team growth and development through effective leadership and mentorship
Build and focus teams in a capital-efficient manner to support current and future pipeline needs
Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
Map out critical path activities through IND-enabling studies and ensure key activities are resourced and executed efficiently
Set and implement strategy for developability assessment and early-stage de-risking
Prepare and present data packages for partnering discussions and investor presentations
Contribute to high-level strategy and key objectives for discovery and development of shuttled therapeutics
Understand and support strategic growth plans of the organization, helping to build and focus internal resources for success
Establish development candidate nomination criteria for novel biotherapeutics with particular focus on developability, balancing timelines, budget, and risk
Identify and outline opportunities for backup molecule discovery and selection
Serve as Manifold's protein therapeutic representative for partnered program(s), providing clear communication with biotherapeutics counterparts at partner organizations
Manage relationships with CDMOs and related CROs, including selection, contract negotiations, and maintaining timelines/budgets