The Creed lab in the Department of Anesthesiology seeks a research scientist with expertise in in vivo electrophysiology to join our team. Chronic pain afflicts over 20% of the population, and is characterized by affective symptoms (anhedonia, apathy and depressed mood) that negatively impact pain management. Research in our lab seeks to understand the basis for these affective symptoms. We focus on synaptic plasticity within genetically-defined neural circuits in the basal ganglia and thalamocortical networks. We combine patch clamp and in vivo electrophysiology, RNA-sequencing, biophysical modeling of neurons and computational models of behavior to understand how chronic pain and opioid analgesics alters plasticity in neural circuits, and how changes in these neural circuits drive negative affect and changes in cognition. We seek to translate (and back translate!) results of our findings. Our ultimate goal is to use these insights to develop novel neuromodulation therapies to treat affective and cognitive symptoms of chronic pain disorders. The successful candidate will apply electrophysiological approaches to multiple collaborative projects in the lab and will have opportunities to independently lead projects. Designs research protocols. Assists in developing and conducting research projects, including experiment design, data analysis and documentation of experiment results.
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Job Type
Full-time
Career Level
Mid Level