Trainee - Cardiovascular Research Institute
About The Position
Details of Research Project: cell-cell communication (CCC) mediated by specific ligand-receptor interaction modulates several functions necessary for maintaining human health. Dysregulation in these interactions are observed in several disease conditions including heart failure, chronic kidney disease, cross-organ fibrosis. Current methods to quantify CCC are limited in terms of a) predicting the impact of these interactions of downstream functions in a cell and b) accounting for the impact on the overall phenotype. The goal of this project is to conduct a comprehensive benchmark of factors such changes in levels of ligands, receptors, and their downstream pathways in order to identify key ligand-receptor interactions associated with cross-organ fibrosis. Goals/Outcomes of the Research Project: The goal of the project is to: Develop a framework to compare CCC across organs Evaluate the impact of ligand-receptor interactions in predicting their downstream pathway activation Creation of a web-portal to host pre-computed cross-organ CCC interactions Preparation of a final report and presentation
Requirements
- High School Diploma or GED required
- Associates or greater depending on department and role.
- None experience
Responsibilities
- The ideal candidate is fluent in Python and R programming languages.
- Experience in data pre-processing, feature extraction methods, supervised and unsupervised machine learning, model evaluation and validation is essential.
- Previous knowledge of single-cell transcriptomics is desirable.
- Performs other related duties assigned.
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What This Job Offers
Career Level
Entry Level
Education Level
High school or GED
