Summer Intern Platform Biology

Arvinas • New Haven, CT

2d • Onsite

About The Position

The Platform Biology summer internship position at Arvinas will focus on evaluating and developing 3D biology to include automation and high-content imaging to support Oncology and Neuroscience. This position will involve cell biology and biochemical techniques, use of automation equipment, and high-content imaging. The candidate will join a collaborative, multi-disciplinary team of biologists, biochemists, biophysicists, and chemists. This is a laboratory-based role that will work to automate the biology and staining of 3D spheroids (and possibly organoids) for deeper understanding of and screening for novel PROTACs. We are looking for a passionate and highly motivated individual who is enthusiastic about novel therapeutic applications, such as degraders, and wants to contribute to exploring new modalities of targeting proteins for degradation across neuroscience, oncology and immune-oncology space. This training opportunity allows the individual to learn the process of early drug discovery in a collaborative environment. This position reports to a Senior Research Scientist, Platform Biology and will be located at our headquarters in New Haven, CT.

Requirements

• The candidate should be a highly motivated fast learner with flexibility and ability to multi-task, as well as a good lab citizen.
• Experience in cell culture is required.
• Ability to work full-time (40 hours per week).
• Arvinas will not be providing VISA sponsorship for this position.
• You must have the ability to work without a need for a current or future VISA sponsorship.
• The duties of this role are generally conducted in a lab environment.
• Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Nice To Haves

• Previous oncology or neuroscience experience is preferred
• Experience with microscopy and high content imaging is a plus.
• Knowledge of ubiquitin-based proteasomal degradation is desired, but not a pre-requisite.
• Preference to Master’s / PhD student currently enrolled in a program with a concentration in cell biology, immunology, pharmacology, biology, or related fields.
• Prior laboratory experience is a plus.

Responsibilities

• Cell culture including sterile technique for mammalian cell lines
• Live-cell assays to monitor, image and analyze 3D spheroids
• Cellular assays working to fix, permeabilize, and use immunofluorescence staining to research methods for 3D spheroid marker infiltration including tissue clearing while automating the staining process
• Develop, run and analyze data using high-content imaging instruments
• Cellular assays to monitor activity of degrader compounds (such as JESS, high-content, luminescence, fluorescence, NanoBRET)
• Data analysis and interpretation, as well as presenting data in team meetings.
• Meeting with key stakeholders outside of the project team to devise future experiments for downstream applications
• Major areas of focus will include utilizing established workflows to guide assay development and technical optimization, evaluating appropriate controls, and troubleshooting.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern